The prognostic significance of preoperative leukocytosis in epithelial ovarian carcinoma: A retrospective cohort study

Kyeong A. So, Jin Hwa Hong, Hye Mi Jin, Jae Won Kim, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective Preoperative leukocytosis is known to be a negative prognostic factor for several gynecologic malignancies, but its relationship with epithelial ovarian carcinoma (EOC) is unknown. We sought to evaluate the prognostic implications of preoperative leukocytosis for women with EOC. Methods We retrospectively reviewed the medical records of patients who underwent primary debulking surgery and adjuvant platinum-based chemotherapy for EOC between January 1993 and October 2011. Associations between leukocytosis and recurrence-free survival (RFS) and overall survival (OS) were determined by univariate analyses. Multivariate Cox proportional hazards regression was used to identify independent prognostic factors for RFS and OS. Results Of 155 women, 23 (14.8%) had leukocytosis and 132 (85.2%) did not have leukocytosis. RFS and OS were significantly shorter for women with leukocytosis than for women without leukocytosis (P = 0.009 and P < 0.0001, respectively). The mortality rate was also higher among women with leukocytosis (P < 0.0001). Multivariate analysis revealed that preoperative leukocytosis (hazard ratio [HR]: 2.15; 95% confidence interval [CI]: 1.55-4.41; P = 0.009), advanced stage (HR: 3.12; 95% CI: 1.44-6.75; P = 0.004), and optimal cytoreduction (HR: 0.38; 95% CI: 0.14-0.70; P = 0.031) were independent prognostic factors for RFS. Additionally, preoperative leukocytosis was independently associated with decreased OS (HR: 7.66; 95% CI: 2.78-21.16; P < 0.0001). Conclusions Among women with EOC, preoperative leukocytosis might be an independent prognostic factor for RFS and OS. A larger-scaled, prospective study is needed to verify these results.

Original languageEnglish
Pages (from-to)551-555
Number of pages5
JournalGynecologic Oncology
Volume132
Issue number3
DOIs
Publication statusPublished - 2014 Mar

    Fingerprint

Keywords

  • Leukocytosis
  • Ovarian cancer
  • Overall survival
  • Recurrence-free survival

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this