The protective effect of inhaled heparin, cromolyn, budesonide, and furosemide on exercise-induced asthma

Hyung Lee Sin Hyung Lee, Jeong Shim Jae Jeong Shim, Youb Lee Sang Youb Lee, Youn Cho Jae Youn Cho, Ho In Kwang Ho In, Hwa Yoo Se Hwa Yoo, Ho Kang Kyung Ho Kang

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Abstract

Background: The purpose of the present study was to determine the protective effect of antiasthmatic activity of inhaled heparin, cromolyn sodium, budesonide, furosemide in exercise-induced asthma(EIA). The other important considerable point of this study was the mechanism of bronchoconstriction on EIA. Methods: Eight subjects with a history of EIA were studied on 5 different experiment days. After obtaining baseline FEV, and FVC, subjects performed a standardized exercise challenge. EIA was assessed by measurement of FEV, before and after exercise. On experiment day 4, the exercise challenge was performed after the subjects inhaled either heparin (1,000 units/kg/day for 5 days), furosemide (1mg/kg for 5 days), cromolyn (4mg/day for 5 days), or budesonide (400 μg /day for 5 days). On experiment day 5, the methacholine bronchial provocation test was performed. On experiment day 3, activated partial thromboplastine time(aPTT) was checked. Results: Maximum decrements of FEV1 (mean±SE) among 0 to 120 minutes after exercise were as follows: heparin was 83.1±4.81% (p = 0.010), furosemide was 80.5±6.87% (p= 0.071), cromolyn was 86.8±6. 53% (p=0.340), and budesonide was 79.4±7.31% (p=0.095). Above medications were compared to the control value (72.5±18.2%) by paired t-test. No medications had effect on PD20 of methacholine bronchial provocation test. The results were control (1.58±0.49μmol), heparin (4.17±1.96μmol), furosemide (1.85±0. 86μmol), cromolyn (2.19±0.89μmol), and budesonide (3.38±1.77μmol), respectively(p>0.05). The inhaled heparin had no effect of anticoagulation. Conclusion: These data demonstrate that inhaled heparin has a protective effect on EIA. The effect of inhaled - The protective effect of inhaled heparin, cromolyn, budesonide, and furosemide on exercise-induced asthma - cromolyn was statistically absent with manufacture's recommended dosage on EIA. So, the dosage of cromolyn should be carefully evaluated in future. Although inhalation of budesonide and furosemide have no statistical significance compared to control, these drugs also have some protective effects on EIA.

Original languageEnglish
Pages (from-to)1188-1198
Number of pages11
JournalTuberculosis and Respiratory Diseases
Volume45
Issue number6
DOIs
Publication statusPublished - 1998

Keywords

  • Budesonide
  • Cromolyn
  • Exercise-induced asthma
  • Furosemide
  • Heparin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Sin Hyung Lee, H. L., Jae Jeong Shim, J. S., Sang Youb Lee, Y. L., Jae Youn Cho, Y. C., Kwang Ho In, H. I., Se Hwa Yoo, H. Y., & Kyung Ho Kang, H. K. (1998). The protective effect of inhaled heparin, cromolyn, budesonide, and furosemide on exercise-induced asthma. Tuberculosis and Respiratory Diseases, 45(6), 1188-1198. https://doi.org/10.4046/trd.1998.45.6.1188