The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: A meta-analysis

Young Ho Lee, Sung Jae Choi, Jong Dae Ji, Gwan Gyu Song

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to determine whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) C1858T polymorphism (rs2476601) confers susceptibility to vasculitis. A meta-analysis was conducted on the PTPN22 C1858T polymorphism across nine comparative studies containing 1,922 vasculitis patients and 11,505 normal control subjects. Meta-analysis showed no association between the T allele and vasculitis in all subjects [odds ratio (OR) 1.046, 95 % confidence interval (CI) 0.755-1.1.451, p = 0.786], and analysis after stratification by ethnicity indicated that the T allele was not associated with vasculitis in Europeans (OR 1.104, 95 % CI 0.798-1.528, p = 0.551). However, meta-analysis showed a significant association between the T allele and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) (OR 1.415, 95 % CI 1.228-1.630, p = 1.59 × 10-6) and Wegener's granulomatosis (WG) (OR 1.829, 95 % CI 1.377-2.431, p = 3.09 × 10 -5). In addition, meta-analysis showed an association between the T allele and WG in ANCA-positive subjects (OR 2.042, 95 % CI 1.534-2.719, p = 1.02 × 10-6), but not in ANCA-negative WG patients (OR 0.595, 95 % CI 0.199-1.781, p = 0.353). This meta-analysis does not show that the PTPN22 C1858T polymorphism is associated with vasculitis susceptibility, but does show that this polymorphism is associated with susceptibility to AAV, WG, and ANCA status in WG.

Original languageEnglish
Pages (from-to)8505-8511
Number of pages7
JournalMolecular biology reports
Volume39
Issue number8
DOIs
Publication statusPublished - 2012 Aug

Keywords

  • Metaanalysis
  • Polymorphism
  • Protein tyrosine phosphatase nonreceptor 22
  • Vasculitis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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