The Recovery of Beta-Cell Function is Critical for Antidiabetic Outcomes of Gastric Bypass in Asian Subjects with Type 2 Diabetes and a Body Mass Index Below 30

Obin Kwon; Yeon Ji Lee; Ji Hee Yu; Min Seon Kim; Yoonseok Heo

doi:10.1007/s11695-016-2455-y

The Recovery of Beta-Cell Function is Critical for Antidiabetic Outcomes of Gastric Bypass in Asian Subjects with Type 2 Diabetes and a Body Mass Index Below 30

Obin Kwon, Yeon Ji Lee, Ji Hee Yu, Min Seon Kim, Yoonseok Heo

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Type 2 diabetes (T2D) in Asian populations is characterized by a lower body mass index (BMI) than in Caucasian cases. This pilot study investigated antidiabetic outcomes after a Roux-en-Y gastric bypass (RYGB) in Asian subjects with T2D and BMI < 30. Fifteen Koreans with poorly controlled T2D and BMI 23–30 underwent RYGB. Two years after RYGB, seven patients achieved HbA_1c < 6.5% without medication (target-achieved). The other cases also showed improved glycemic control. The insulin secretory response during an oral glucose tolerance test was significantly restored in the target-achieved group. Postoperative changes in insulin sensitivity and body weight did not differ between these groups. Beta-cell function improvement is an important determinant of the long-term antidiabetic outcomes of RYGB in Asian subjects with BMI < 30.

Original language	English
Pages (from-to)	541-544
Number of pages	4
Journal	Obesity Surgery
Volume	27
Issue number	2
DOIs	https://doi.org/10.1007/s11695-016-2455-y
Publication status	Published - 2017 Feb 1
Externally published	Yes

Keywords

Asian
Beta-cell
Body mass index
Gastric bypass
Type 2 diabetes

ASJC Scopus subject areas

Surgery
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11695-016-2455-y

Cite this

@article{eb068d272b7441e9b53a7d8c8c9ed389,

title = "The Recovery of Beta-Cell Function is Critical for Antidiabetic Outcomes of Gastric Bypass in Asian Subjects with Type 2 Diabetes and a Body Mass Index Below 30",

abstract = "Type 2 diabetes (T2D) in Asian populations is characterized by a lower body mass index (BMI) than in Caucasian cases. This pilot study investigated antidiabetic outcomes after a Roux-en-Y gastric bypass (RYGB) in Asian subjects with T2D and BMI < 30. Fifteen Koreans with poorly controlled T2D and BMI 23–30 underwent RYGB. Two years after RYGB, seven patients achieved HbA1c < 6.5% without medication (target-achieved). The other cases also showed improved glycemic control. The insulin secretory response during an oral glucose tolerance test was significantly restored in the target-achieved group. Postoperative changes in insulin sensitivity and body weight did not differ between these groups. Beta-cell function improvement is an important determinant of the long-term antidiabetic outcomes of RYGB in Asian subjects with BMI < 30.",

keywords = "Asian, Beta-cell, Body mass index, Gastric bypass, Type 2 diabetes",

author = "Obin Kwon and Lee, {Yeon Ji} and Yu, {Ji Hee} and Kim, {Min Seon} and Yoonseok Heo",

note = "Funding Information: This work was supported by grants from the Korean Health Technology R&D Project (H15C1322), Ministry of Health & Welfare, Republic of Korea (for Y.H.), and the National Research Foundation of Korea (2013M3C7A1056024, 2015M3A9E7029172 for M.-S.K.). Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",

year = "2017",

month = feb,

day = "1",

doi = "10.1007/s11695-016-2455-y",

language = "English",

volume = "27",

pages = "541--544",

journal = "Obesity Surgery",

issn = "0960-8923",

publisher = "Springer New York",

number = "2",

}

TY - JOUR

T1 - The Recovery of Beta-Cell Function is Critical for Antidiabetic Outcomes of Gastric Bypass in Asian Subjects with Type 2 Diabetes and a Body Mass Index Below 30

AU - Kwon, Obin

AU - Lee, Yeon Ji

AU - Yu, Ji Hee

AU - Kim, Min Seon

AU - Heo, Yoonseok

N1 - Funding Information: This work was supported by grants from the Korean Health Technology R&D Project (H15C1322), Ministry of Health & Welfare, Republic of Korea (for Y.H.), and the National Research Foundation of Korea (2013M3C7A1056024, 2015M3A9E7029172 for M.-S.K.). Publisher Copyright: © 2016, Springer Science+Business Media New York.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Type 2 diabetes (T2D) in Asian populations is characterized by a lower body mass index (BMI) than in Caucasian cases. This pilot study investigated antidiabetic outcomes after a Roux-en-Y gastric bypass (RYGB) in Asian subjects with T2D and BMI < 30. Fifteen Koreans with poorly controlled T2D and BMI 23–30 underwent RYGB. Two years after RYGB, seven patients achieved HbA1c < 6.5% without medication (target-achieved). The other cases also showed improved glycemic control. The insulin secretory response during an oral glucose tolerance test was significantly restored in the target-achieved group. Postoperative changes in insulin sensitivity and body weight did not differ between these groups. Beta-cell function improvement is an important determinant of the long-term antidiabetic outcomes of RYGB in Asian subjects with BMI < 30.

AB - Type 2 diabetes (T2D) in Asian populations is characterized by a lower body mass index (BMI) than in Caucasian cases. This pilot study investigated antidiabetic outcomes after a Roux-en-Y gastric bypass (RYGB) in Asian subjects with T2D and BMI < 30. Fifteen Koreans with poorly controlled T2D and BMI 23–30 underwent RYGB. Two years after RYGB, seven patients achieved HbA1c < 6.5% without medication (target-achieved). The other cases also showed improved glycemic control. The insulin secretory response during an oral glucose tolerance test was significantly restored in the target-achieved group. Postoperative changes in insulin sensitivity and body weight did not differ between these groups. Beta-cell function improvement is an important determinant of the long-term antidiabetic outcomes of RYGB in Asian subjects with BMI < 30.

KW - Asian

KW - Beta-cell

KW - Body mass index

KW - Gastric bypass

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84996523913&partnerID=8YFLogxK

U2 - 10.1007/s11695-016-2455-y

DO - 10.1007/s11695-016-2455-y

M3 - Article

C2 - 27878422

AN - SCOPUS:84996523913

SN - 0960-8923

VL - 27

SP - 541

EP - 544

JO - Obesity Surgery

JF - Obesity Surgery

IS - 2

ER -

The Recovery of Beta-Cell Function is Critical for Antidiabetic Outcomes of Gastric Bypass in Asian Subjects with Type 2 Diabetes and a Body Mass Index Below 30

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this