The regulatory diversity of the mammalian adenylyl cyclases

Eui Ju Choi, Zhengui Xia, Enrique C. Villacres, Daniel R. Storm

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Clones for six mammalian adenylyl cyclases have recently been isolated. One of these enzymes, the type I calmodulin-sensitive adenylyl cyclase, is neurospecific and is implicated in neuroplasticity. We propose that the type I adenylyl cyclase may be important for learning and memory because it allows Ca2+-amplified cAMP signals, synergism between Ca2+ and cAMP-activated kinases, and positive feedback regulation of Ca2+ channels by cAMP-dependent protein kinase.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalCurrent Opinion in Cell Biology
Volume5
Issue number2
DOIs
Publication statusPublished - 1993 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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