The regulatory diversity of the mammalian adenylyl cyclases

Eui Ju Choi, Zhengui Xia, Enrique C. Villacres, Daniel R. Storm

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Clones for six mammalian adenylyl cyclases have recently been isolated. One of these enzymes, the type I calmodulin-sensitive adenylyl cyclase, is neurospecific and is implicated in neuroplasticity. We propose that the type I adenylyl cyclase may be important for learning and memory because it allows Ca2+-amplified cAMP signals, synergism between Ca2+ and cAMP-activated kinases, and positive feedback regulation of Ca2+ channels by cAMP-dependent protein kinase.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalCurrent Opinion in Cell Biology
Volume5
Issue number2
Publication statusPublished - 1993 Dec 1
Externally publishedYes

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Adenylyl Cyclases
Neuronal Plasticity
Calmodulin
Cyclic AMP-Dependent Protein Kinases
Phosphotransferases
Clone Cells
Learning
Enzymes
adenylyl cyclase 1

ASJC Scopus subject areas

  • Cell Biology

Cite this

Choi, E. J., Xia, Z., Villacres, E. C., & Storm, D. R. (1993). The regulatory diversity of the mammalian adenylyl cyclases. Current Opinion in Cell Biology, 5(2), 269-273.

The regulatory diversity of the mammalian adenylyl cyclases. / Choi, Eui Ju; Xia, Zhengui; Villacres, Enrique C.; Storm, Daniel R.

In: Current Opinion in Cell Biology, Vol. 5, No. 2, 01.12.1993, p. 269-273.

Research output: Contribution to journalArticle

Choi, EJ, Xia, Z, Villacres, EC & Storm, DR 1993, 'The regulatory diversity of the mammalian adenylyl cyclases', Current Opinion in Cell Biology, vol. 5, no. 2, pp. 269-273.
Choi, Eui Ju ; Xia, Zhengui ; Villacres, Enrique C. ; Storm, Daniel R. / The regulatory diversity of the mammalian adenylyl cyclases. In: Current Opinion in Cell Biology. 1993 ; Vol. 5, No. 2. pp. 269-273.
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