The relation between chronic kidney disease and cerebral microbleeds: Difference between patients with and without diabetes

Wi Sun Ryu, Seung Hoon Lee, Chi Kyung Kim, Beom Joon Kim, Byung Woo Yoon

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Cerebral microbleeds are an important radiologic marker of bleeding-prone brain and have been reported to be associated with the increased risk of intracerebral haemorrhage. Aims: We sought to examine the association of chronic kidney disease with cerebral microbleeds, and determine whether the association differs between patients with and without diabetes. Methods: A total of 909 patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data (including serum creatinine levels) and documented the presence and numbers of microbleeds. Kidney function was estimated by using the Modification of Diet in Renal Disease formula. We categorized estimated glomerular filtration rates into moderate to severe, mild, and normal (<60, 60-90, and >90ml/min/1·73m2, respectively). Results: Cerebral microbleeds is most frequent in the moderate-to-severe chronic kidney disease group (45·6%). In patients without diabetes, mild and moderate-to-severe chronic kidney disease was found to be independently associated with the presence of cerebral microbleeds (adjusted odds ratio, 1·68; 95% confidence interval, 1·04-2·71 and adjusted odds ratio, 3·74; 95% confidence interval, 1·87-7·47) compared with normal kidney function. In patients with diabetes, however, this relationship was not found. Furthermore, ordinal logistic regression analysis revealed that an increased serum creatinine level and a reduced kidney function were associated with the number of cerebral microbleeds. Conclusion: We found that chronic kidney disease is independently associated with cerebral microbleeds in patients without diabetes but not in patients with diabetes.

Original languageEnglish
Pages (from-to)551-557
Number of pages7
JournalInternational Journal of Stroke
Volume7
Issue number7
DOIs
Publication statusPublished - 2012 Oct 1
Externally publishedYes

Fingerprint

Chronic Renal Insufficiency
Kidney
Creatinine
Odds Ratio
Confidence Intervals
Diet Therapy
Cerebral Hemorrhage
Serum
Glomerular Filtration Rate
Logistic Models
Stroke
Regression Analysis
Demography
Hemorrhage
Brain

Keywords

  • Cerebral microbleeds
  • Chronic kidney disease
  • Ischemic stroke

ASJC Scopus subject areas

  • Neurology

Cite this

The relation between chronic kidney disease and cerebral microbleeds : Difference between patients with and without diabetes. / Ryu, Wi Sun; Lee, Seung Hoon; Kim, Chi Kyung; Kim, Beom Joon; Yoon, Byung Woo.

In: International Journal of Stroke, Vol. 7, No. 7, 01.10.2012, p. 551-557.

Research output: Contribution to journalArticle

@article{2c698459435a41e9bbb6bf619673c58a,
title = "The relation between chronic kidney disease and cerebral microbleeds: Difference between patients with and without diabetes",
abstract = "Background: Cerebral microbleeds are an important radiologic marker of bleeding-prone brain and have been reported to be associated with the increased risk of intracerebral haemorrhage. Aims: We sought to examine the association of chronic kidney disease with cerebral microbleeds, and determine whether the association differs between patients with and without diabetes. Methods: A total of 909 patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data (including serum creatinine levels) and documented the presence and numbers of microbleeds. Kidney function was estimated by using the Modification of Diet in Renal Disease formula. We categorized estimated glomerular filtration rates into moderate to severe, mild, and normal (<60, 60-90, and >90ml/min/1·73m2, respectively). Results: Cerebral microbleeds is most frequent in the moderate-to-severe chronic kidney disease group (45·6{\%}). In patients without diabetes, mild and moderate-to-severe chronic kidney disease was found to be independently associated with the presence of cerebral microbleeds (adjusted odds ratio, 1·68; 95{\%} confidence interval, 1·04-2·71 and adjusted odds ratio, 3·74; 95{\%} confidence interval, 1·87-7·47) compared with normal kidney function. In patients with diabetes, however, this relationship was not found. Furthermore, ordinal logistic regression analysis revealed that an increased serum creatinine level and a reduced kidney function were associated with the number of cerebral microbleeds. Conclusion: We found that chronic kidney disease is independently associated with cerebral microbleeds in patients without diabetes but not in patients with diabetes.",
keywords = "Cerebral microbleeds, Chronic kidney disease, Ischemic stroke",
author = "Ryu, {Wi Sun} and Lee, {Seung Hoon} and Kim, {Chi Kyung} and Kim, {Beom Joon} and Yoon, {Byung Woo}",
year = "2012",
month = "10",
day = "1",
doi = "10.1111/j.1747-4949.2011.00732.x",
language = "English",
volume = "7",
pages = "551--557",
journal = "International Journal of Stroke",
issn = "1747-4930",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - The relation between chronic kidney disease and cerebral microbleeds

T2 - Difference between patients with and without diabetes

AU - Ryu, Wi Sun

AU - Lee, Seung Hoon

AU - Kim, Chi Kyung

AU - Kim, Beom Joon

AU - Yoon, Byung Woo

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Background: Cerebral microbleeds are an important radiologic marker of bleeding-prone brain and have been reported to be associated with the increased risk of intracerebral haemorrhage. Aims: We sought to examine the association of chronic kidney disease with cerebral microbleeds, and determine whether the association differs between patients with and without diabetes. Methods: A total of 909 patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data (including serum creatinine levels) and documented the presence and numbers of microbleeds. Kidney function was estimated by using the Modification of Diet in Renal Disease formula. We categorized estimated glomerular filtration rates into moderate to severe, mild, and normal (<60, 60-90, and >90ml/min/1·73m2, respectively). Results: Cerebral microbleeds is most frequent in the moderate-to-severe chronic kidney disease group (45·6%). In patients without diabetes, mild and moderate-to-severe chronic kidney disease was found to be independently associated with the presence of cerebral microbleeds (adjusted odds ratio, 1·68; 95% confidence interval, 1·04-2·71 and adjusted odds ratio, 3·74; 95% confidence interval, 1·87-7·47) compared with normal kidney function. In patients with diabetes, however, this relationship was not found. Furthermore, ordinal logistic regression analysis revealed that an increased serum creatinine level and a reduced kidney function were associated with the number of cerebral microbleeds. Conclusion: We found that chronic kidney disease is independently associated with cerebral microbleeds in patients without diabetes but not in patients with diabetes.

AB - Background: Cerebral microbleeds are an important radiologic marker of bleeding-prone brain and have been reported to be associated with the increased risk of intracerebral haemorrhage. Aims: We sought to examine the association of chronic kidney disease with cerebral microbleeds, and determine whether the association differs between patients with and without diabetes. Methods: A total of 909 patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data (including serum creatinine levels) and documented the presence and numbers of microbleeds. Kidney function was estimated by using the Modification of Diet in Renal Disease formula. We categorized estimated glomerular filtration rates into moderate to severe, mild, and normal (<60, 60-90, and >90ml/min/1·73m2, respectively). Results: Cerebral microbleeds is most frequent in the moderate-to-severe chronic kidney disease group (45·6%). In patients without diabetes, mild and moderate-to-severe chronic kidney disease was found to be independently associated with the presence of cerebral microbleeds (adjusted odds ratio, 1·68; 95% confidence interval, 1·04-2·71 and adjusted odds ratio, 3·74; 95% confidence interval, 1·87-7·47) compared with normal kidney function. In patients with diabetes, however, this relationship was not found. Furthermore, ordinal logistic regression analysis revealed that an increased serum creatinine level and a reduced kidney function were associated with the number of cerebral microbleeds. Conclusion: We found that chronic kidney disease is independently associated with cerebral microbleeds in patients without diabetes but not in patients with diabetes.

KW - Cerebral microbleeds

KW - Chronic kidney disease

KW - Ischemic stroke

UR - http://www.scopus.com/inward/record.url?scp=84866513528&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866513528&partnerID=8YFLogxK

U2 - 10.1111/j.1747-4949.2011.00732.x

DO - 10.1111/j.1747-4949.2011.00732.x

M3 - Article

C2 - 22243603

AN - SCOPUS:84866513528

VL - 7

SP - 551

EP - 557

JO - International Journal of Stroke

JF - International Journal of Stroke

SN - 1747-4930

IS - 7

ER -