The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms

Young Ho Jung; Ju Hee Seo; Hyung Young Kim; Ji Won Kwon; Byoung Ju Kim; Hyo Bin Kim; So Yeon Lee; Gwang Cheon Jang; Dae Jin Song; Woo Kyung Kim; Jung Yeon Shim; Soo Jong Hong

doi:10.1002/ppul.22978

The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms

Young Ho Jung, Ju Hee Seo, Hyung Young Kim, Ji Won Kwon, Byoung Ju Kim, Hyo Bin Kim, So Yeon Lee, Gwang Cheon Jang, Dae Jin Song, Woo Kyung Kim, Jung Yeon Shim, Soo Jong Hong

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Background: Asthma is a complex genetic disorder that is associated with both genetic and environmental factors. The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma.

Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 1,341 elementary school children and 919 nursery children in Seoul, Korea. TLR4 (rs1927911), CD14 (rs2569190), and IL-13 (rs20541) polymorphisms were genotyped by the TaqMan assay.

Results: In elementary school and nursery children, parental history of asthma (adjusted odds ratio [aOR] 2.56 [95% CI1.16-5.63], aOR 3.60 [95% CI1.66-7.76], respectively), and past history of bronchiolitis (aOR 3.11 [95% CI1.84-5.24], aOR 3.94 [95% CI 2.27-6.84], respectively) were independent riskfactors for asthma diagnosis. When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13polymorphism and no past history of bronchiolitis, children with CTor TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.

Conclusions: Family history of asthma or allergic rhinitis and past history of bronchiolitis could be independent riskfactors for the development of childhood asthma. The relationship between asthma and bronchiolitis is modified by the TLR4, CD14, and IL-13 polymorphisms in Korean children.

Original language	English
Pages (from-to)	8-16
Number of pages	9
Journal	Pediatric Pulmonology
Volume	50
Issue number	1
DOIs	https://doi.org/10.1002/ppul.22978
Publication status	Published - 2015 Jan 1
Externally published	Yes

Keywords

Asthma
Bronchiolitis
Gene-environment interaction
Polymorphism
Prevalence
Risk factor

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

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10.1002/ppul.22978

Cite this

@article{8ed9d4a6bb9d4c1e81d4ae5b508408ae,

title = "The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms",

abstract = "Background: Asthma is a complex genetic disorder that is associated with both genetic and environmental factors. The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma.Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 1,341 elementary school children and 919 nursery children in Seoul, Korea. TLR4 (rs1927911), CD14 (rs2569190), and IL-13 (rs20541) polymorphisms were genotyped by the TaqMan assay.Results: In elementary school and nursery children, parental history of asthma (adjusted odds ratio [aOR] 2.56 [95% CI1.16-5.63], aOR 3.60 [95% CI1.66-7.76], respectively), and past history of bronchiolitis (aOR 3.11 [95% CI1.84-5.24], aOR 3.94 [95% CI 2.27-6.84], respectively) were independent riskfactors for asthma diagnosis. When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13polymorphism and no past history of bronchiolitis, children with CTor TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.Conclusions: Family history of asthma or allergic rhinitis and past history of bronchiolitis could be independent riskfactors for the development of childhood asthma. The relationship between asthma and bronchiolitis is modified by the TLR4, CD14, and IL-13 polymorphisms in Korean children.",

keywords = "Asthma, Bronchiolitis, Gene-environment interaction, Polymorphism, Prevalence, Risk factor",

author = "Jung, {Young Ho} and Seo, {Ju Hee} and Kim, {Hyung Young} and Kwon, {Ji Won} and Kim, {Byoung Ju} and Kim, {Hyo Bin} and Lee, {So Yeon} and Jang, {Gwang Cheon} and Song, {Dae Jin} and Kim, {Woo Kyung} and Shim, {Jung Yeon} and Hong, {Soo Jong}",

note = "Publisher Copyright: {\textcopyright} 2013 Wiley Periodicals, Inc.",

year = "2015",

month = jan,

day = "1",

doi = "10.1002/ppul.22978",

language = "English",

volume = "50",

pages = "8--16",

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T1 - The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms

AU - Jung, Young Ho

AU - Seo, Ju Hee

AU - Kim, Hyung Young

AU - Kwon, Ji Won

AU - Kim, Byoung Ju

AU - Kim, Hyo Bin

AU - Lee, So Yeon

AU - Jang, Gwang Cheon

AU - Song, Dae Jin

AU - Kim, Woo Kyung

AU - Shim, Jung Yeon

AU - Hong, Soo Jong

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Asthma is a complex genetic disorder that is associated with both genetic and environmental factors. The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma.Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 1,341 elementary school children and 919 nursery children in Seoul, Korea. TLR4 (rs1927911), CD14 (rs2569190), and IL-13 (rs20541) polymorphisms were genotyped by the TaqMan assay.Results: In elementary school and nursery children, parental history of asthma (adjusted odds ratio [aOR] 2.56 [95% CI1.16-5.63], aOR 3.60 [95% CI1.66-7.76], respectively), and past history of bronchiolitis (aOR 3.11 [95% CI1.84-5.24], aOR 3.94 [95% CI 2.27-6.84], respectively) were independent riskfactors for asthma diagnosis. When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13polymorphism and no past history of bronchiolitis, children with CTor TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.Conclusions: Family history of asthma or allergic rhinitis and past history of bronchiolitis could be independent riskfactors for the development of childhood asthma. The relationship between asthma and bronchiolitis is modified by the TLR4, CD14, and IL-13 polymorphisms in Korean children.

AB - Background: Asthma is a complex genetic disorder that is associated with both genetic and environmental factors. The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma.Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 1,341 elementary school children and 919 nursery children in Seoul, Korea. TLR4 (rs1927911), CD14 (rs2569190), and IL-13 (rs20541) polymorphisms were genotyped by the TaqMan assay.Results: In elementary school and nursery children, parental history of asthma (adjusted odds ratio [aOR] 2.56 [95% CI1.16-5.63], aOR 3.60 [95% CI1.66-7.76], respectively), and past history of bronchiolitis (aOR 3.11 [95% CI1.84-5.24], aOR 3.94 [95% CI 2.27-6.84], respectively) were independent riskfactors for asthma diagnosis. When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13polymorphism and no past history of bronchiolitis, children with CTor TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.Conclusions: Family history of asthma or allergic rhinitis and past history of bronchiolitis could be independent riskfactors for the development of childhood asthma. The relationship between asthma and bronchiolitis is modified by the TLR4, CD14, and IL-13 polymorphisms in Korean children.

KW - Asthma

KW - Bronchiolitis

KW - Gene-environment interaction

KW - Polymorphism

KW - Prevalence

KW - Risk factor

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The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms

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