The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms

Young Ho Jung, Ju Hee Seo, Hyung Young Kim, Ji Won Kwon, Byoung Ju Kim, Hyo Bin Kim, So Yeon Lee, Gwang Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Jung Yeon Shim, Soo Jong Hong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Asthma is a complex genetic disorder that is associated with both genetic and environmental factors. The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma.

Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 1,341 elementary school children and 919 nursery children in Seoul, Korea. TLR4 (rs1927911), CD14 (rs2569190), and IL-13 (rs20541) polymorphisms were genotyped by the TaqMan assay.

Results: In elementary school and nursery children, parental history of asthma (adjusted odds ratio [aOR] 2.56 [95% CI1.16-5.63], aOR 3.60 [95% CI1.66-7.76], respectively), and past history of bronchiolitis (aOR 3.11 [95% CI1.84-5.24], aOR 3.94 [95% CI 2.27-6.84], respectively) were independent riskfactors for asthma diagnosis. When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13polymorphism and no past history of bronchiolitis, children with CTor TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.

Conclusions: Family history of asthma or allergic rhinitis and past history of bronchiolitis could be independent riskfactors for the development of childhood asthma. The relationship between asthma and bronchiolitis is modified by the TLR4, CD14, and IL-13 polymorphisms in Korean children.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalPediatric Pulmonology
Volume50
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Bronchiolitis
Toll-Like Receptor 4
Interleukin-13
Asthma
Odds Ratio
Nursery Schools
Inborn Genetic Diseases
Nurseries
Korea
Hypersensitivity

Keywords

  • Asthma
  • Bronchiolitis
  • Gene-environment interaction
  • Polymorphism
  • Prevalence
  • Risk factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Jung, Y. H., Seo, J. H., Kim, H. Y., Kwon, J. W., Kim, B. J., Kim, H. B., ... Hong, S. J. (2015). The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms. Pediatric Pulmonology, 50(1), 8-16. https://doi.org/10.1002/ppul.22978

The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms. / Jung, Young Ho; Seo, Ju Hee; Kim, Hyung Young; Kwon, Ji Won; Kim, Byoung Ju; Kim, Hyo Bin; Lee, So Yeon; Jang, Gwang Cheon; Song, Dae-Jin; Kim, Woo Kyung; Shim, Jung Yeon; Hong, Soo Jong.

In: Pediatric Pulmonology, Vol. 50, No. 1, 01.01.2015, p. 8-16.

Research output: Contribution to journalArticle

Jung, YH, Seo, JH, Kim, HY, Kwon, JW, Kim, BJ, Kim, HB, Lee, SY, Jang, GC, Song, D-J, Kim, WK, Shim, JY & Hong, SJ 2015, 'The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms', Pediatric Pulmonology, vol. 50, no. 1, pp. 8-16. https://doi.org/10.1002/ppul.22978
Jung, Young Ho ; Seo, Ju Hee ; Kim, Hyung Young ; Kwon, Ji Won ; Kim, Byoung Ju ; Kim, Hyo Bin ; Lee, So Yeon ; Jang, Gwang Cheon ; Song, Dae-Jin ; Kim, Woo Kyung ; Shim, Jung Yeon ; Hong, Soo Jong. / The relationship between asthma and bronchiolitis is modified by TLR4, CD14, and IL-13 polymorphisms. In: Pediatric Pulmonology. 2015 ; Vol. 50, No. 1. pp. 8-16.
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AU - Seo, Ju Hee

AU - Kim, Hyung Young

AU - Kwon, Ji Won

AU - Kim, Byoung Ju

AU - Kim, Hyo Bin

AU - Lee, So Yeon

AU - Jang, Gwang Cheon

AU - Song, Dae-Jin

AU - Kim, Woo Kyung

AU - Shim, Jung Yeon

AU - Hong, Soo Jong

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N2 - Background: Asthma is a complex genetic disorder that is associated with both genetic and environmental factors. The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma.Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 1,341 elementary school children and 919 nursery children in Seoul, Korea. TLR4 (rs1927911), CD14 (rs2569190), and IL-13 (rs20541) polymorphisms were genotyped by the TaqMan assay.Results: In elementary school and nursery children, parental history of asthma (adjusted odds ratio [aOR] 2.56 [95% CI1.16-5.63], aOR 3.60 [95% CI1.66-7.76], respectively), and past history of bronchiolitis (aOR 3.11 [95% CI1.84-5.24], aOR 3.94 [95% CI 2.27-6.84], respectively) were independent riskfactors for asthma diagnosis. When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13polymorphism and no past history of bronchiolitis, children with CTor TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.Conclusions: Family history of asthma or allergic rhinitis and past history of bronchiolitis could be independent riskfactors for the development of childhood asthma. The relationship between asthma and bronchiolitis is modified by the TLR4, CD14, and IL-13 polymorphisms in Korean children.

AB - Background: Asthma is a complex genetic disorder that is associated with both genetic and environmental factors. The aim of study was to investigate the combined effect of toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), and interleukin-13 (IL-13) polymorphisms and bronchiolitis in the development of childhood asthma.Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 1,341 elementary school children and 919 nursery children in Seoul, Korea. TLR4 (rs1927911), CD14 (rs2569190), and IL-13 (rs20541) polymorphisms were genotyped by the TaqMan assay.Results: In elementary school and nursery children, parental history of asthma (adjusted odds ratio [aOR] 2.56 [95% CI1.16-5.63], aOR 3.60 [95% CI1.66-7.76], respectively), and past history of bronchiolitis (aOR 3.11 [95% CI1.84-5.24], aOR 3.94 [95% CI 2.27-6.84], respectively) were independent riskfactors for asthma diagnosis. When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13polymorphism and no past history of bronchiolitis, children with CTor TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.Conclusions: Family history of asthma or allergic rhinitis and past history of bronchiolitis could be independent riskfactors for the development of childhood asthma. The relationship between asthma and bronchiolitis is modified by the TLR4, CD14, and IL-13 polymorphisms in Korean children.

KW - Asthma

KW - Bronchiolitis

KW - Gene-environment interaction

KW - Polymorphism

KW - Prevalence

KW - Risk factor

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