The relationship between cardiorespiratory fitness and aortic stiffness in women with central obesity

Jacqueline A. Augustine, Eun Sun Yoon, Jina Choo, Kevin S. Heffernan, Sae Young Jae

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To examine the association between cardiorespiratory fitness and aortic stiffness in women with central obesity. The secondary purpose was to examine whether traditional and nontraditional cardiovascular risk factors mediate the relationship between cardiorespiratory fitness and aortic stiffness. Materials and Methods: Eighty-seven centrally obese women (age, 42 ± 9 years, [body mass index (BMI)] 28 ± 3 kg/m2) participated in this cross-sectional study. Central obesity was defined as a waist circumference >85 cm. Pulse wave velocity (PWV) was obtained from the carotid and femoral pulse sites using applanation tonometry to measure aortic stiffness. Maximal aerobic capacity (VO2 Max) was estimated using a submaximal walk test and taken as a measure of cardiorespiratory fitness. Potential correlates of both cardiorespiratory fitness and aortic stiffness examined in this study included the following: triglycerides (TG), C-reactive protein (CRP), homeostasis model assessment of insulin resistance index (HOMA-IR), and pulsatile load (i.e., heart rate × aortic pulse pressure [aPP]). Results: Pearson's bivariate correlations indicated that estimated VO2 Max was inversely associated with PWV (r = -0.330, p <0.05). Using hierarchical multiple regression, the association between estimated VO2 Max and PWV was no longer significant after controlling for traditional and nontraditional cardiovascular risk factors, age, BMI, TG, CRP, HOMA-IR, and pulsatile load (β = 0.121, p > 0.05). Conclusion: In centrally obese women, cardiorespiratory fitness was inversely associated with aortic stiffness. Associations were not independent of traditional and nontraditional cardiovascular disease (CVD) risk factors. This suggests that higher levels of cardiorespiratory fitness may indirectly reduce aortic stiffness through its beneficial effects on traditional and nontraditional CVD risk factors in women with central obesity.

Original languageEnglish
Pages (from-to)680-686
Number of pages7
JournalJournal of Women's Health
Volume25
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1

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Vascular Stiffness
Abdominal Obesity
Pulse Wave Analysis
Cardiovascular Diseases
Manometry
Waist Circumference
Thigh
C-Reactive Protein
Pulse
Insulin Resistance
Cardiorespiratory Fitness
Arterial Pressure
Triglycerides
Body Mass Index
Homeostasis
Cross-Sectional Studies
Heart Rate

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The relationship between cardiorespiratory fitness and aortic stiffness in women with central obesity. / Augustine, Jacqueline A.; Yoon, Eun Sun; Choo, Jina; Heffernan, Kevin S.; Jae, Sae Young.

In: Journal of Women's Health, Vol. 25, No. 7, 01.07.2016, p. 680-686.

Research output: Contribution to journalArticle

Augustine, Jacqueline A. ; Yoon, Eun Sun ; Choo, Jina ; Heffernan, Kevin S. ; Jae, Sae Young. / The relationship between cardiorespiratory fitness and aortic stiffness in women with central obesity. In: Journal of Women's Health. 2016 ; Vol. 25, No. 7. pp. 680-686.
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