The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients

Sang Mi Kwak, Youn Seon Choi, Ho Min Yoon, Dae Gyun Kim, Seung Hun Song, Young Jae Lee, Chang Hwan Yeom, Su Jin Koh, Jeanno Park, Myung Ah Lee, Sang Yeon Suh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Although many cancer patients receiving palliative care experience distressing levels of fatigue, no well-designed studies have investigated contributing factors in Korean patients. We conducted a cross-sectional study using the Brief Fatigue Inventory-K (BFI-K) to measure fatigue while assessing a variety of possible correlates. Ninety patients with incurable cancer in the terminal stage (median survival: 27 days) participated in a structured interview and questionnaire related to their medical conditions and underwent blood sampling for laboratory data and cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Body mass index, dyspnea, the Eastern Cooperative Oncology Group performance status, and levels of albumin, blood urea nitrogen (BUN), total bilirubin, and C-reactive protein were significantly associated with fatigue. However, levels of the two proinflammatory cytokines, IL-6 and TNF-α, were not significantly correlated with the BFI-K score. In stepwise multiple linear regression, fatigue was related to elevated BUN (β = 0.376, p = 0.002), severe pain intensity (β = 0.349, p = 0.004), and impaired performance status (β = 0.268, p = 0.027), but not related to levels of inflammatory cytokines. In conclusion, the diagnostic work-up and therapeutic plan for patients with cancer-related fatigue should include an evaluation of laboratory parameters, pain severity, and physical performance.

Original languageEnglish
Pages (from-to)275-282
Number of pages8
JournalPalliative Medicine
Volume26
Issue number3
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Terminally Ill
Fatigue
Interleukin-6
Tumor Necrosis Factor-alpha
Neoplasms
Blood Urea Nitrogen
Cytokines
Pain
Equipment and Supplies
Palliative Care
Bilirubin
Dyspnea
C-Reactive Protein
Albumins
Linear Models
Body Mass Index
Cross-Sectional Studies
Interviews
Survival

Keywords

  • Blood urea nitrogen
  • cytokine
  • fatigue
  • pain
  • physical performance
  • terminal cancer

ASJC Scopus subject areas

  • Medicine(all)
  • Anesthesiology and Pain Medicine

Cite this

The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients. / Kwak, Sang Mi; Choi, Youn Seon; Yoon, Ho Min; Kim, Dae Gyun; Song, Seung Hun; Lee, Young Jae; Yeom, Chang Hwan; Koh, Su Jin; Park, Jeanno; Lee, Myung Ah; Suh, Sang Yeon.

In: Palliative Medicine, Vol. 26, No. 3, 01.04.2012, p. 275-282.

Research output: Contribution to journalArticle

Kwak, SM, Choi, YS, Yoon, HM, Kim, DG, Song, SH, Lee, YJ, Yeom, CH, Koh, SJ, Park, J, Lee, MA & Suh, SY 2012, 'The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients', Palliative Medicine, vol. 26, no. 3, pp. 275-282. https://doi.org/10.1177/0269216311406991
Kwak, Sang Mi ; Choi, Youn Seon ; Yoon, Ho Min ; Kim, Dae Gyun ; Song, Seung Hun ; Lee, Young Jae ; Yeom, Chang Hwan ; Koh, Su Jin ; Park, Jeanno ; Lee, Myung Ah ; Suh, Sang Yeon. / The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients. In: Palliative Medicine. 2012 ; Vol. 26, No. 3. pp. 275-282.
@article{98d2e58e8bbf4b779d0d7d83a44a3fbd,
title = "The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients",
abstract = "Although many cancer patients receiving palliative care experience distressing levels of fatigue, no well-designed studies have investigated contributing factors in Korean patients. We conducted a cross-sectional study using the Brief Fatigue Inventory-K (BFI-K) to measure fatigue while assessing a variety of possible correlates. Ninety patients with incurable cancer in the terminal stage (median survival: 27 days) participated in a structured interview and questionnaire related to their medical conditions and underwent blood sampling for laboratory data and cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Body mass index, dyspnea, the Eastern Cooperative Oncology Group performance status, and levels of albumin, blood urea nitrogen (BUN), total bilirubin, and C-reactive protein were significantly associated with fatigue. However, levels of the two proinflammatory cytokines, IL-6 and TNF-α, were not significantly correlated with the BFI-K score. In stepwise multiple linear regression, fatigue was related to elevated BUN (β = 0.376, p = 0.002), severe pain intensity (β = 0.349, p = 0.004), and impaired performance status (β = 0.268, p = 0.027), but not related to levels of inflammatory cytokines. In conclusion, the diagnostic work-up and therapeutic plan for patients with cancer-related fatigue should include an evaluation of laboratory parameters, pain severity, and physical performance.",
keywords = "Blood urea nitrogen, cytokine, fatigue, pain, physical performance, terminal cancer",
author = "Kwak, {Sang Mi} and Choi, {Youn Seon} and Yoon, {Ho Min} and Kim, {Dae Gyun} and Song, {Seung Hun} and Lee, {Young Jae} and Yeom, {Chang Hwan} and Koh, {Su Jin} and Jeanno Park and Lee, {Myung Ah} and Suh, {Sang Yeon}",
year = "2012",
month = "4",
day = "1",
doi = "10.1177/0269216311406991",
language = "English",
volume = "26",
pages = "275--282",
journal = "Palliative Medicine",
issn = "0269-2163",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - The relationship between interleukin-6, tumor necrosis factor-α, and fatigue in terminally ill cancer patients

AU - Kwak, Sang Mi

AU - Choi, Youn Seon

AU - Yoon, Ho Min

AU - Kim, Dae Gyun

AU - Song, Seung Hun

AU - Lee, Young Jae

AU - Yeom, Chang Hwan

AU - Koh, Su Jin

AU - Park, Jeanno

AU - Lee, Myung Ah

AU - Suh, Sang Yeon

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Although many cancer patients receiving palliative care experience distressing levels of fatigue, no well-designed studies have investigated contributing factors in Korean patients. We conducted a cross-sectional study using the Brief Fatigue Inventory-K (BFI-K) to measure fatigue while assessing a variety of possible correlates. Ninety patients with incurable cancer in the terminal stage (median survival: 27 days) participated in a structured interview and questionnaire related to their medical conditions and underwent blood sampling for laboratory data and cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Body mass index, dyspnea, the Eastern Cooperative Oncology Group performance status, and levels of albumin, blood urea nitrogen (BUN), total bilirubin, and C-reactive protein were significantly associated with fatigue. However, levels of the two proinflammatory cytokines, IL-6 and TNF-α, were not significantly correlated with the BFI-K score. In stepwise multiple linear regression, fatigue was related to elevated BUN (β = 0.376, p = 0.002), severe pain intensity (β = 0.349, p = 0.004), and impaired performance status (β = 0.268, p = 0.027), but not related to levels of inflammatory cytokines. In conclusion, the diagnostic work-up and therapeutic plan for patients with cancer-related fatigue should include an evaluation of laboratory parameters, pain severity, and physical performance.

AB - Although many cancer patients receiving palliative care experience distressing levels of fatigue, no well-designed studies have investigated contributing factors in Korean patients. We conducted a cross-sectional study using the Brief Fatigue Inventory-K (BFI-K) to measure fatigue while assessing a variety of possible correlates. Ninety patients with incurable cancer in the terminal stage (median survival: 27 days) participated in a structured interview and questionnaire related to their medical conditions and underwent blood sampling for laboratory data and cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Body mass index, dyspnea, the Eastern Cooperative Oncology Group performance status, and levels of albumin, blood urea nitrogen (BUN), total bilirubin, and C-reactive protein were significantly associated with fatigue. However, levels of the two proinflammatory cytokines, IL-6 and TNF-α, were not significantly correlated with the BFI-K score. In stepwise multiple linear regression, fatigue was related to elevated BUN (β = 0.376, p = 0.002), severe pain intensity (β = 0.349, p = 0.004), and impaired performance status (β = 0.268, p = 0.027), but not related to levels of inflammatory cytokines. In conclusion, the diagnostic work-up and therapeutic plan for patients with cancer-related fatigue should include an evaluation of laboratory parameters, pain severity, and physical performance.

KW - Blood urea nitrogen

KW - cytokine

KW - fatigue

KW - pain

KW - physical performance

KW - terminal cancer

UR - http://www.scopus.com/inward/record.url?scp=84863366905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863366905&partnerID=8YFLogxK

U2 - 10.1177/0269216311406991

DO - 10.1177/0269216311406991

M3 - Article

C2 - 21807751

AN - SCOPUS:84863366905

VL - 26

SP - 275

EP - 282

JO - Palliative Medicine

JF - Palliative Medicine

SN - 0269-2163

IS - 3

ER -