The relationship between perioperative nausea and vomiting and serum serotonin concentrations in patients undergoing cesarean section under epidural anesthesia

Byung Gun Lim, Sang Sik Choi, Yu Jin Jeong, Young Jin Lim, Yong Chul Kim, Kyoung Un Park, Dong Kyu Lee, Kyoung Lee Mi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Serotonin-also known as 5-hydroxytryptamine or 5-HT-can induce nausea and vomiting (NV) by peripheral mechanisms via the activation of 5-HT3 receptors. In this study, we observed perioperative N V, including intraoperative N V, and changes in serum 5-HT concentrations. We evaluated the relationship between perioperative NV and serum 5-HT levels in patients undergoing cesarean section under epidural anesthesia, and carried out a pilot study to determine if further studies on a larger scale were justifed. Methods: Twenty-eight patients who were scheduled for cesarean section under epidural anesthesia were included in the study. Patients were assigned to 2 groups according to the occurrence of NV after induction, i.e., an NV-positive or an NV-negative group. Serum 5-HT concentrations were measured before induction, at the time that NV occurred (in the case of the NV-positive group) or 5 min after the umbilical cord clamping (in the case of the NV-negative group) during surgery, and at 2 h postoperatively. Results: NV occurred in 10 of the 28 patients. No significant differences in serum 5-HT concentrations were found within or between the two groups. Conclusions: Tis study suggests that there is no correlation between serum 5-HT concentration and the occurrence of perioperative NV in patients undergoing cesarean section under epidural anesthesia, and the findings do not seem to support further investigations regarding a possible relationship between serum 5-HT concentration and perioperative NV.

Original languageEnglish
Pages (from-to)384-390
Number of pages7
JournalKorean journal of anesthesiology
Volume67
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Cesarean section
  • Epidural anesthesia
  • Perioperative nausea and vomiting
  • Serum serotonin

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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