The relationship between preeclampsia, pregnancy-induced hypertension and maternal risk of breast cancer

A meta-analysis

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24 Citations (Scopus)

Abstract

Background. It has long been recognized that some human breast cancers are hormone dependent. Preeclampsia is a syndrome of pregnancy defined by the onset of hypertension and proteinuria and characterized by dysfunction of the maternal endothelium. Many hormonal changes occur with preeclampsia, and we hypothesize that these changes may influence the risk of maternal breast cancer. We also analyzed the relation between pregnancy-induced hypertension (PIH) and maternal risk of breast cancer. Methods. Among 13 relevant publications about preeclampsia and six relevant publications about PIH, some studies find preeclampsia associated with a lower risk of breast cancer, but others did not. Therefore, these results are inconclusive. We conducted meta-analysis to evaluate more precisely the relationship between preeclampsia, PIH and maternal risk of breast cancer. Results. The pooled estimate of the hazard ratio (HR) associated with preeclampsia was 0.86 (95% CI 0.73-1.01), and that associated with PIH was 0.83 (0.66-1.06), both based on the random effects model. Conclusion. Some suggestive but not entirely consistent nor conclusive evidence was found on the association between the history of preeclampsia or PIH with the subsequent risk of breast cancer.

Original languageEnglish
Pages (from-to)1643-1648
Number of pages6
JournalActa Oncologica
Volume52
Issue number8
DOIs
Publication statusPublished - 2013 Oct 18

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Pregnancy Induced Hypertension
Pre-Eclampsia
Meta-Analysis
Mothers
Breast Neoplasms
Publications
Proteinuria
Endothelium
History
Hormones
Hypertension
Pregnancy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

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title = "The relationship between preeclampsia, pregnancy-induced hypertension and maternal risk of breast cancer: A meta-analysis",
abstract = "Background. It has long been recognized that some human breast cancers are hormone dependent. Preeclampsia is a syndrome of pregnancy defined by the onset of hypertension and proteinuria and characterized by dysfunction of the maternal endothelium. Many hormonal changes occur with preeclampsia, and we hypothesize that these changes may influence the risk of maternal breast cancer. We also analyzed the relation between pregnancy-induced hypertension (PIH) and maternal risk of breast cancer. Methods. Among 13 relevant publications about preeclampsia and six relevant publications about PIH, some studies find preeclampsia associated with a lower risk of breast cancer, but others did not. Therefore, these results are inconclusive. We conducted meta-analysis to evaluate more precisely the relationship between preeclampsia, PIH and maternal risk of breast cancer. Results. The pooled estimate of the hazard ratio (HR) associated with preeclampsia was 0.86 (95{\%} CI 0.73-1.01), and that associated with PIH was 0.83 (0.66-1.06), both based on the random effects model. Conclusion. Some suggestive but not entirely consistent nor conclusive evidence was found on the association between the history of preeclampsia or PIH with the subsequent risk of breast cancer.",
author = "Kim, {Jung Sun} and Kang, {Eun Joo} and Woo, {Ok Hee} and Park, {Kyong Hwa} and Woo, {Sang- Uk} and Dae-Sik Yang and Aeree Kim and Lee, {Jae Bok} and Kim, {Yeul Hong} and Kim, {Jun Suk} and Seo, {Jae Hong}",
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AU - Kang, Eun Joo

AU - Woo, Ok Hee

AU - Park, Kyong Hwa

AU - Woo, Sang- Uk

AU - Yang, Dae-Sik

AU - Kim, Aeree

AU - Lee, Jae Bok

AU - Kim, Yeul Hong

AU - Kim, Jun Suk

AU - Seo, Jae Hong

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background. It has long been recognized that some human breast cancers are hormone dependent. Preeclampsia is a syndrome of pregnancy defined by the onset of hypertension and proteinuria and characterized by dysfunction of the maternal endothelium. Many hormonal changes occur with preeclampsia, and we hypothesize that these changes may influence the risk of maternal breast cancer. We also analyzed the relation between pregnancy-induced hypertension (PIH) and maternal risk of breast cancer. Methods. Among 13 relevant publications about preeclampsia and six relevant publications about PIH, some studies find preeclampsia associated with a lower risk of breast cancer, but others did not. Therefore, these results are inconclusive. We conducted meta-analysis to evaluate more precisely the relationship between preeclampsia, PIH and maternal risk of breast cancer. Results. The pooled estimate of the hazard ratio (HR) associated with preeclampsia was 0.86 (95% CI 0.73-1.01), and that associated with PIH was 0.83 (0.66-1.06), both based on the random effects model. Conclusion. Some suggestive but not entirely consistent nor conclusive evidence was found on the association between the history of preeclampsia or PIH with the subsequent risk of breast cancer.

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