The relationship between prolactin response and clinical efficacy of risperidone in acute psychotic inpatients

Bun Hee Lee, Yong Ku Kim

Research output: Contribution to journalArticle

35 Citations (Scopus)


Hyperprolactinemia can be induced by dopamine D2 receptor-binding drugs such as antipsychotic drugs. The author investigated the relationship between changes in prolactin (PRL) and clinical efficacy of risperidone. In this study, 27 acute psychotic inpatients completed a 12-week trial of risperidone. At baseline and at 2, 4, 8, and 12 weeks after beginning medication, the author measured PRL, assessed hyperprolactinemia-related symptoms, and administered the Brief Psychotic Rating Scale (BPRS). Risperidone treatment significantly elevated serum PRL level (range: 26.9 ng/ml-320.0 ng/ml). The increases of PRL in females were higher than males. The changes in serum PRL levels were not significantly correlated with the improvements in total BPRS scores. PRL-related symptoms such as irregular menstruation, galactorrhea, or erectile dysfunction occurred in nine subjects (7 females and 2 males) whose serum PRL levels increase very highly after 2 weeks of risperidone. In conclusion, our study suggests that the changes in serum PRL levels were not significantly correlated with clinical efficacy of risperidone.

Original languageEnglish
Pages (from-to)658-662
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number4
Publication statusPublished - 2006 Jun 1



  • Clinical efficacy
  • Prolactin
  • Risperidone
  • Schizoaffective disorder
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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