Abstract
Hyperprolactinemia can be induced by dopamine D2 receptor-binding drugs such as antipsychotic drugs. The author investigated the relationship between changes in prolactin (PRL) and clinical efficacy of risperidone. In this study, 27 acute psychotic inpatients completed a 12-week trial of risperidone. At baseline and at 2, 4, 8, and 12 weeks after beginning medication, the author measured PRL, assessed hyperprolactinemia-related symptoms, and administered the Brief Psychotic Rating Scale (BPRS). Risperidone treatment significantly elevated serum PRL level (range: 26.9 ng/ml-320.0 ng/ml). The increases of PRL in females were higher than males. The changes in serum PRL levels were not significantly correlated with the improvements in total BPRS scores. PRL-related symptoms such as irregular menstruation, galactorrhea, or erectile dysfunction occurred in nine subjects (7 females and 2 males) whose serum PRL levels increase very highly after 2 weeks of risperidone. In conclusion, our study suggests that the changes in serum PRL levels were not significantly correlated with clinical efficacy of risperidone.
| Original language | English |
|---|---|
| Pages (from-to) | 658-662 |
| Number of pages | 5 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2006 Jun 1 |
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Keywords
- Clinical efficacy
- Prolactin
- Risperidone
- Schizoaffective disorder
- Schizophrenia
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology
Cite this
The relationship between prolactin response and clinical efficacy of risperidone in acute psychotic inpatients. / Lee, Bun Hee; Kim, Yong Ku.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 30, No. 4, 01.06.2006, p. 658-662.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The relationship between prolactin response and clinical efficacy of risperidone in acute psychotic inpatients
AU - Lee, Bun Hee
AU - Kim, Yong Ku
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Hyperprolactinemia can be induced by dopamine D2 receptor-binding drugs such as antipsychotic drugs. The author investigated the relationship between changes in prolactin (PRL) and clinical efficacy of risperidone. In this study, 27 acute psychotic inpatients completed a 12-week trial of risperidone. At baseline and at 2, 4, 8, and 12 weeks after beginning medication, the author measured PRL, assessed hyperprolactinemia-related symptoms, and administered the Brief Psychotic Rating Scale (BPRS). Risperidone treatment significantly elevated serum PRL level (range: 26.9 ng/ml-320.0 ng/ml). The increases of PRL in females were higher than males. The changes in serum PRL levels were not significantly correlated with the improvements in total BPRS scores. PRL-related symptoms such as irregular menstruation, galactorrhea, or erectile dysfunction occurred in nine subjects (7 females and 2 males) whose serum PRL levels increase very highly after 2 weeks of risperidone. In conclusion, our study suggests that the changes in serum PRL levels were not significantly correlated with clinical efficacy of risperidone.
AB - Hyperprolactinemia can be induced by dopamine D2 receptor-binding drugs such as antipsychotic drugs. The author investigated the relationship between changes in prolactin (PRL) and clinical efficacy of risperidone. In this study, 27 acute psychotic inpatients completed a 12-week trial of risperidone. At baseline and at 2, 4, 8, and 12 weeks after beginning medication, the author measured PRL, assessed hyperprolactinemia-related symptoms, and administered the Brief Psychotic Rating Scale (BPRS). Risperidone treatment significantly elevated serum PRL level (range: 26.9 ng/ml-320.0 ng/ml). The increases of PRL in females were higher than males. The changes in serum PRL levels were not significantly correlated with the improvements in total BPRS scores. PRL-related symptoms such as irregular menstruation, galactorrhea, or erectile dysfunction occurred in nine subjects (7 females and 2 males) whose serum PRL levels increase very highly after 2 weeks of risperidone. In conclusion, our study suggests that the changes in serum PRL levels were not significantly correlated with clinical efficacy of risperidone.
KW - Clinical efficacy
KW - Prolactin
KW - Risperidone
KW - Schizoaffective disorder
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=33646103894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646103894&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2005.11.037
DO - 10.1016/j.pnpbp.2005.11.037
M3 - Article
C2 - 16466670
AN - SCOPUS:33646103894
VL - 30
SP - 658
EP - 662
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 4
ER -