The relationship between twin births and maternal risk of breast cancer

A meta-analysis

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Women who undergo a greater number of menstrual cycles may be at increased risk of breast cancer, possibly due to cumulative exposure to ovarian hormones. Pregnancy reduces the lifetime number of menstrual cycles and also influences the levels of ovarian hormones. Twin pregnancies differ from singleton pregnancies in both hormone levels and perinatal changes. To date, a meta-analysis on the effects of twin birth on the risk of maternal breast cancer has not been conducted. Among 17 relevant publications identified in a systematic search, some suggest that twin births may be associated with lower breast cancer risk but others do not; therefore, the results are inconclusive. Although our pooled results of all 17 published studies did not show a reduced maternal risk of breast cancer for twin births (HR 0.94; 95% CI = 0.87-1.02; P = 0.127), a trend toward reduced maternal risk of breast cancer was identified in a subgroup analysis of cohort studies (HR 0.91; 95% CI = 0.83-1.01; P = 0.068). The results of this meta-analysis suggest that twin pregnancy does not significantly decrease the maternal risk of breast cancer.

Original languageEnglish
Pages (from-to)671-677
Number of pages7
JournalBreast Cancer Research and Treatment
Volume131
Issue number2
DOIs
Publication statusPublished - 2012 Jan 1

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Meta-Analysis
Mothers
Parturition
Breast Neoplasms
Twin Pregnancy
Hormones
Menstrual Cycle
Pregnancy
Publications
Cohort Studies

Keywords

  • Breast cancer
  • Meta-analysis
  • Twin births

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "The relationship between twin births and maternal risk of breast cancer: A meta-analysis",
abstract = "Women who undergo a greater number of menstrual cycles may be at increased risk of breast cancer, possibly due to cumulative exposure to ovarian hormones. Pregnancy reduces the lifetime number of menstrual cycles and also influences the levels of ovarian hormones. Twin pregnancies differ from singleton pregnancies in both hormone levels and perinatal changes. To date, a meta-analysis on the effects of twin birth on the risk of maternal breast cancer has not been conducted. Among 17 relevant publications identified in a systematic search, some suggest that twin births may be associated with lower breast cancer risk but others do not; therefore, the results are inconclusive. Although our pooled results of all 17 published studies did not show a reduced maternal risk of breast cancer for twin births (HR 0.94; 95{\%} CI = 0.87-1.02; P = 0.127), a trend toward reduced maternal risk of breast cancer was identified in a subgroup analysis of cohort studies (HR 0.91; 95{\%} CI = 0.83-1.01; P = 0.068). The results of this meta-analysis suggest that twin pregnancy does not significantly decrease the maternal risk of breast cancer.",
keywords = "Breast cancer, Meta-analysis, Twin births",
author = "Kim, {Hye Sook} and Woo, {Ok Hee} and Park, {Kyong Hwa} and Woo, {Sang- Uk} and Dae-Sik Yang and Aeree Kim and Lee, {Eun Sook} and Lee, {Jae Bok} and Kim, {Yeul Hong} and Kim, {Jun Suk} and Seo, {Jae Hong}",
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AU - Yang, Dae-Sik

AU - Kim, Aeree

AU - Lee, Eun Sook

AU - Lee, Jae Bok

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AU - Kim, Jun Suk

AU - Seo, Jae Hong

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