The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis

Sundo Jung, Yoon Kyung Park, Jung Hoon Shin, Hyunji Lee, Soo Young Kim, Gap Ryol Lee, Se Ho Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

TGF-β-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.

Original languageEnglish
Pages (from-to)547-554
Number of pages8
JournalExperimental and Molecular Medicine
Volume42
Issue number8
DOIs
Publication statusPublished - 2010

Keywords

  • Antigen-presenting cells
  • Antigens
  • Arthritis
  • CD1d
  • Experimental
  • Immune tolerance
  • Natural killer T-cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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