The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis

Claudia Hass, Jens Lohrmann, Verónica Albrecht, Uta Sweere, Florian Hummel, Sang Dong Yoo, Ildoo Hwang, Tong Zhu, Eberhard Schäfer, Jörg Kudla, Klaus Harter

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Hormones are important regulators of plant growth and development. In Arabidopsis, perception of the phytohormones ethylene and cytokinln is accomplished by a family of sensor histidine kinases including ethylene-resistant (ETR) 1 and cytokinin-response (CRE) 1. We identified the Arabidopsis response regulator 2 (ARR2) as a signalling component functioning downstream of ETR1 in ethylene signal transduction. Analyses of loss-of-function and ARR2-overexpressing lines as well as functional assays in protoplasts indicate an important role of ARR2 in mediating ethylene responses. Additional investigations indicate that an ETR1-initiated phosphorelay regulates the transcription factor activity of ARR2. This mechanism may create a novel signal transfer from endoplasmic reticulum-associated ETR1 to the nucleus for the regulation of ethylene-response genes. Furthermore, global expression profiling revealed a complex ARR2-involving two-component network that interferes with a multitude of different signalling pathways and thereby contributes to the highly integrated signal processing machinery in higher plants.

Original languageEnglish
Pages (from-to)3290-3302
Number of pages13
JournalEMBO Journal
Volume23
Issue number16
DOIs
Publication statusPublished - 2004 Aug 18

Keywords

  • Expression profiling
  • Phosphorelay
  • Phytohormone signalling
  • Response regulator
  • Two-component system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Hass, C., Lohrmann, J., Albrecht, V., Sweere, U., Hummel, F., Yoo, S. D., Hwang, I., Zhu, T., Schäfer, E., Kudla, J., & Harter, K. (2004). The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis. EMBO Journal, 23(16), 3290-3302. https://doi.org/10.1038/sj.emboj.7600337