The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis

Claudia Hass; Jens Lohrmann; Verónica Albrecht; Uta Sweere; Florian Hummel; Sang Dong Yoo; Ildoo Hwang; Tong Zhu; Eberhard Schäfer; Jörg Kudla; Klaus Harter

doi:10.1038/sj.emboj.7600337

The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis

Claudia Hass, Jens Lohrmann, Verónica Albrecht, Uta Sweere, Florian Hummel, Sang Dong Yoo, Ildoo Hwang, Tong Zhu, Eberhard Schäfer, Jörg Kudla, Klaus Harter

Research output: Contribution to journal › Article › peer-review

160 Citations (Scopus)

Abstract

Hormones are important regulators of plant growth and development. In Arabidopsis, perception of the phytohormones ethylene and cytokinln is accomplished by a family of sensor histidine kinases including ethylene-resistant (ETR) 1 and cytokinin-response (CRE) 1. We identified the Arabidopsis response regulator 2 (ARR2) as a signalling component functioning downstream of ETR1 in ethylene signal transduction. Analyses of loss-of-function and ARR2-overexpressing lines as well as functional assays in protoplasts indicate an important role of ARR2 in mediating ethylene responses. Additional investigations indicate that an ETR1-initiated phosphorelay regulates the transcription factor activity of ARR2. This mechanism may create a novel signal transfer from endoplasmic reticulum-associated ETR1 to the nucleus for the regulation of ethylene-response genes. Furthermore, global expression profiling revealed a complex ARR2-involving two-component network that interferes with a multitude of different signalling pathways and thereby contributes to the highly integrated signal processing machinery in higher plants.

Original language	English
Pages (from-to)	3290-3302
Number of pages	13
Journal	EMBO Journal
Volume	23
Issue number	16
DOIs	https://doi.org/10.1038/sj.emboj.7600337
Publication status	Published - 2004 Aug 18

Keywords

Expression profiling
Phosphorelay
Phytohormone signalling
Response regulator
Two-component system

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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title = "The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis",

abstract = "Hormones are important regulators of plant growth and development. In Arabidopsis, perception of the phytohormones ethylene and cytokinln is accomplished by a family of sensor histidine kinases including ethylene-resistant (ETR) 1 and cytokinin-response (CRE) 1. We identified the Arabidopsis response regulator 2 (ARR2) as a signalling component functioning downstream of ETR1 in ethylene signal transduction. Analyses of loss-of-function and ARR2-overexpressing lines as well as functional assays in protoplasts indicate an important role of ARR2 in mediating ethylene responses. Additional investigations indicate that an ETR1-initiated phosphorelay regulates the transcription factor activity of ARR2. This mechanism may create a novel signal transfer from endoplasmic reticulum-associated ETR1 to the nucleus for the regulation of ethylene-response genes. Furthermore, global expression profiling revealed a complex ARR2-involving two-component network that interferes with a multitude of different signalling pathways and thereby contributes to the highly integrated signal processing machinery in higher plants.",

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author = "Claudia Hass and Jens Lohrmann and Ver{\'o}nica Albrecht and Uta Sweere and Florian Hummel and Yoo, {Sang Dong} and Ildoo Hwang and Tong Zhu and Eberhard Sch{\"a}fer and J{\"o}rg Kudla and Klaus Harter",

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AU - Hass, Claudia

AU - Lohrmann, Jens

AU - Albrecht, Verónica

AU - Sweere, Uta

AU - Hummel, Florian

AU - Yoo, Sang Dong

AU - Hwang, Ildoo

AU - Zhu, Tong

AU - Schäfer, Eberhard

AU - Kudla, Jörg

AU - Harter, Klaus

PY - 2004/8/18

Y1 - 2004/8/18

N2 - Hormones are important regulators of plant growth and development. In Arabidopsis, perception of the phytohormones ethylene and cytokinln is accomplished by a family of sensor histidine kinases including ethylene-resistant (ETR) 1 and cytokinin-response (CRE) 1. We identified the Arabidopsis response regulator 2 (ARR2) as a signalling component functioning downstream of ETR1 in ethylene signal transduction. Analyses of loss-of-function and ARR2-overexpressing lines as well as functional assays in protoplasts indicate an important role of ARR2 in mediating ethylene responses. Additional investigations indicate that an ETR1-initiated phosphorelay regulates the transcription factor activity of ARR2. This mechanism may create a novel signal transfer from endoplasmic reticulum-associated ETR1 to the nucleus for the regulation of ethylene-response genes. Furthermore, global expression profiling revealed a complex ARR2-involving two-component network that interferes with a multitude of different signalling pathways and thereby contributes to the highly integrated signal processing machinery in higher plants.

AB - Hormones are important regulators of plant growth and development. In Arabidopsis, perception of the phytohormones ethylene and cytokinln is accomplished by a family of sensor histidine kinases including ethylene-resistant (ETR) 1 and cytokinin-response (CRE) 1. We identified the Arabidopsis response regulator 2 (ARR2) as a signalling component functioning downstream of ETR1 in ethylene signal transduction. Analyses of loss-of-function and ARR2-overexpressing lines as well as functional assays in protoplasts indicate an important role of ARR2 in mediating ethylene responses. Additional investigations indicate that an ETR1-initiated phosphorelay regulates the transcription factor activity of ARR2. This mechanism may create a novel signal transfer from endoplasmic reticulum-associated ETR1 to the nucleus for the regulation of ethylene-response genes. Furthermore, global expression profiling revealed a complex ARR2-involving two-component network that interferes with a multitude of different signalling pathways and thereby contributes to the highly integrated signal processing machinery in higher plants.

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The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis

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