The ribonuclease l-dependent antiviral roles of human 2′,5′- oligoadenylate synthetase family members against hepatitis C virus

Young Chan Kwon, Ju Il Kang, Soon B. Hwang, Byung Yoon Ahn

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The latent ribonuclease RNase L and the interferon-inducible 2′,5′-oligoadenylate synthetase (OAS) have been implicated in the antiviral response against hepatitis C virus (HCV). However, the specific roles of these enzymes against HCV have not been fully elucidated. In this study, a scarce endogenous expression and RNA degrading activity of RNase L in human hepatoma Huh7 cells enabled us to demonstrate the antiviral activity of RNase L against HCV replication through the transient expression of the enzyme. The antiviral potential of specific members of the OAS family was further examined through overexpression and RNA interference approaches. Our data suggested that among the members of the OAS family, OAS1 p46 and OAS3 p100 mediate the RNase l-dependent antiviral activity against HCV.

Original languageEnglish
Pages (from-to)156-164
Number of pages9
JournalFEBS Letters
Volume587
Issue number2
DOIs
Publication statusPublished - 2013 Jan 16

Keywords

  • 2′,5′-Oligoadenylate synthetase
  • Antiviral protein
  • Hepatitis C virus
  • RNase L

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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