The risk of lymph node metastasis based on myometrial invasion and tumor grade in endometrioid uterine cancers

A multicenter, retrospective korean study

Kwang Beom Lee, Kyung Do Ki, Jong Min Lee, Jae Kwan Lee, Jae Weon Kim, Chi Heum Cho, Seok Mo Kim, Sang Yoon Park, Dae Hoon Jeong, Ki Tae Kim

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background. Knowledge of the risk factors for lymph node metastasis (LNM) is necessary to treat patients with endometrioid uterine cancer to optimize and further individualize treatment. This study was designed to determine the risk of LNM based on myometrial invasion and tumor grade in endometrioid uterine cancer. Methods. The authors retrospectively reviewed the medical records and pathological findings of 834 patients who underwent surgical staging, including pelvic lymphadenectomy with or without para-aortic lymphadenectomy, for endometrioid uterine cancer from 2002 to 2008 in Korea. Results. Of the 834 patients with endometrioid uterine cancer, 107 (12.8%) patients had LNM. Sixty-one (57%) patients had only pelvic LNM, 39 (36.4%) had pelvic and para-aortic LNM, and 7 (6.6%) had isolated para-aortic LNM. Tumor grade, myometrial invasion, tumor diameter, cervical extension, lymphovascular space invasion, and adnexal involvement were found to be significant predictors of LNM. Of 215 patients with no myometrial invasion and tumor grade I/II, only 1 (0.47%) had LNM. However, in other patients, the risk of LNM was significant and at least >3.5%. Furthermore, the risk of LNM was found to be well correlated with increases in myometrial invasion and tumor grade based on subgroup analyses, when patients with no myometrial invasion and tumor grade I/II were used as a reference group (p <0.0001). Conclusions. Patients with endometrioid uterine cancers with no myometrial invasion and tumor grade I/II might have minimal risk of LNM, whereas others might require complete pelvic and para-aortic lymphadenectomy for surgical staging.

Original languageEnglish
Pages (from-to)2882-2887
Number of pages6
JournalAnnals of Surgical Oncology
Volume16
Issue number10
DOIs
Publication statusPublished - 2009 Oct 1

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Uterine Neoplasms
Retrospective Studies
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Lymph Node Excision
Korea
Medical Records

ASJC Scopus subject areas

  • Surgery
  • Oncology

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The risk of lymph node metastasis based on myometrial invasion and tumor grade in endometrioid uterine cancers : A multicenter, retrospective korean study. / Lee, Kwang Beom; Ki, Kyung Do; Lee, Jong Min; Lee, Jae Kwan; Kim, Jae Weon; Cho, Chi Heum; Kim, Seok Mo; Park, Sang Yoon; Jeong, Dae Hoon; Kim, Ki Tae.

In: Annals of Surgical Oncology, Vol. 16, No. 10, 01.10.2009, p. 2882-2887.

Research output: Contribution to journalArticle

Lee, Kwang Beom ; Ki, Kyung Do ; Lee, Jong Min ; Lee, Jae Kwan ; Kim, Jae Weon ; Cho, Chi Heum ; Kim, Seok Mo ; Park, Sang Yoon ; Jeong, Dae Hoon ; Kim, Ki Tae. / The risk of lymph node metastasis based on myometrial invasion and tumor grade in endometrioid uterine cancers : A multicenter, retrospective korean study. In: Annals of Surgical Oncology. 2009 ; Vol. 16, No. 10. pp. 2882-2887.
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title = "The risk of lymph node metastasis based on myometrial invasion and tumor grade in endometrioid uterine cancers: A multicenter, retrospective korean study",
abstract = "Background. Knowledge of the risk factors for lymph node metastasis (LNM) is necessary to treat patients with endometrioid uterine cancer to optimize and further individualize treatment. This study was designed to determine the risk of LNM based on myometrial invasion and tumor grade in endometrioid uterine cancer. Methods. The authors retrospectively reviewed the medical records and pathological findings of 834 patients who underwent surgical staging, including pelvic lymphadenectomy with or without para-aortic lymphadenectomy, for endometrioid uterine cancer from 2002 to 2008 in Korea. Results. Of the 834 patients with endometrioid uterine cancer, 107 (12.8{\%}) patients had LNM. Sixty-one (57{\%}) patients had only pelvic LNM, 39 (36.4{\%}) had pelvic and para-aortic LNM, and 7 (6.6{\%}) had isolated para-aortic LNM. Tumor grade, myometrial invasion, tumor diameter, cervical extension, lymphovascular space invasion, and adnexal involvement were found to be significant predictors of LNM. Of 215 patients with no myometrial invasion and tumor grade I/II, only 1 (0.47{\%}) had LNM. However, in other patients, the risk of LNM was significant and at least >3.5{\%}. Furthermore, the risk of LNM was found to be well correlated with increases in myometrial invasion and tumor grade based on subgroup analyses, when patients with no myometrial invasion and tumor grade I/II were used as a reference group (p <0.0001). Conclusions. Patients with endometrioid uterine cancers with no myometrial invasion and tumor grade I/II might have minimal risk of LNM, whereas others might require complete pelvic and para-aortic lymphadenectomy for surgical staging.",
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T1 - The risk of lymph node metastasis based on myometrial invasion and tumor grade in endometrioid uterine cancers

T2 - A multicenter, retrospective korean study

AU - Lee, Kwang Beom

AU - Ki, Kyung Do

AU - Lee, Jong Min

AU - Lee, Jae Kwan

AU - Kim, Jae Weon

AU - Cho, Chi Heum

AU - Kim, Seok Mo

AU - Park, Sang Yoon

AU - Jeong, Dae Hoon

AU - Kim, Ki Tae

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Background. Knowledge of the risk factors for lymph node metastasis (LNM) is necessary to treat patients with endometrioid uterine cancer to optimize and further individualize treatment. This study was designed to determine the risk of LNM based on myometrial invasion and tumor grade in endometrioid uterine cancer. Methods. The authors retrospectively reviewed the medical records and pathological findings of 834 patients who underwent surgical staging, including pelvic lymphadenectomy with or without para-aortic lymphadenectomy, for endometrioid uterine cancer from 2002 to 2008 in Korea. Results. Of the 834 patients with endometrioid uterine cancer, 107 (12.8%) patients had LNM. Sixty-one (57%) patients had only pelvic LNM, 39 (36.4%) had pelvic and para-aortic LNM, and 7 (6.6%) had isolated para-aortic LNM. Tumor grade, myometrial invasion, tumor diameter, cervical extension, lymphovascular space invasion, and adnexal involvement were found to be significant predictors of LNM. Of 215 patients with no myometrial invasion and tumor grade I/II, only 1 (0.47%) had LNM. However, in other patients, the risk of LNM was significant and at least >3.5%. Furthermore, the risk of LNM was found to be well correlated with increases in myometrial invasion and tumor grade based on subgroup analyses, when patients with no myometrial invasion and tumor grade I/II were used as a reference group (p <0.0001). Conclusions. Patients with endometrioid uterine cancers with no myometrial invasion and tumor grade I/II might have minimal risk of LNM, whereas others might require complete pelvic and para-aortic lymphadenectomy for surgical staging.

AB - Background. Knowledge of the risk factors for lymph node metastasis (LNM) is necessary to treat patients with endometrioid uterine cancer to optimize and further individualize treatment. This study was designed to determine the risk of LNM based on myometrial invasion and tumor grade in endometrioid uterine cancer. Methods. The authors retrospectively reviewed the medical records and pathological findings of 834 patients who underwent surgical staging, including pelvic lymphadenectomy with or without para-aortic lymphadenectomy, for endometrioid uterine cancer from 2002 to 2008 in Korea. Results. Of the 834 patients with endometrioid uterine cancer, 107 (12.8%) patients had LNM. Sixty-one (57%) patients had only pelvic LNM, 39 (36.4%) had pelvic and para-aortic LNM, and 7 (6.6%) had isolated para-aortic LNM. Tumor grade, myometrial invasion, tumor diameter, cervical extension, lymphovascular space invasion, and adnexal involvement were found to be significant predictors of LNM. Of 215 patients with no myometrial invasion and tumor grade I/II, only 1 (0.47%) had LNM. However, in other patients, the risk of LNM was significant and at least >3.5%. Furthermore, the risk of LNM was found to be well correlated with increases in myometrial invasion and tumor grade based on subgroup analyses, when patients with no myometrial invasion and tumor grade I/II were used as a reference group (p <0.0001). Conclusions. Patients with endometrioid uterine cancers with no myometrial invasion and tumor grade I/II might have minimal risk of LNM, whereas others might require complete pelvic and para-aortic lymphadenectomy for surgical staging.

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