The role of CD4+CD25bright regulatory T cells in the maintenance of pregnancy, premature rupture of membranes, and labor

Hyun Joo Seol, Min Jeong Oh, Ji Eun Lim, Nan Hee Jung, Soo Young Yoon, Hai Joong Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: The aim of this study was to evaluale the changes of the regulatory T cell subset in peripheral blood caused by gestational age and premature rupture of membrains (PROM) with or without labor to verofy the role of regulatory T cells in-pregnancy. Patients and Methods: We investigated reglatory T cell digribution in the peripheral blood of pregnancies during the first trimester (group I, n = 2), the second trimester (group II, n = 12), and the third trimester without PROM and labor (group III, n = 15). In addition, we evaluated pregnancies in the third trimester complicated by PROM (group IV, n = 4) and labor with no complication by PROM (Group V, n = 5). Comparisons were made with non-pregnant controls (group VI, n = 4) using flow cytometry. Results: During uncomplicated pregnancy, the CD4+CD25bright regulatory T cell population decreased with advancing gestational age (group I = 3.35 ± 0.47, group II = 2.91 ± 1.44, group III = 2.81 ± 1.36, group VI = 2.52 ± 0.71, p = NS). When we compared group IV with group III and V to evaluate the changes of the regulatory T cells with PROM, the CD4+CD25bright regulatory T cell population was significantly decreased in group IV compared to group III (p = 0.001) and group V (p = 0.026). Conclusion: The present results revealed that the regulatory T cell population increased in early pregnancy but decreased in pregnancies complicated by PROM, indicating that regulatory T cells might be related to the maintenance of pregnancy.

Original languageEnglish
Pages (from-to)366-371
Number of pages6
JournalYonsei medical journal
Volume49
Issue number3
DOIs
Publication statusPublished - 2008 Jun

Keywords

  • Pregnancy
  • Premature rupture of membranes
  • Regulatory T cells

ASJC Scopus subject areas

  • Medicine(all)

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