The role of clusterin in in vitro ischemia of human retinal endothelial cells

Jeong Hun Kim, Young Suk Yu, Jin Hyoung Kim, Kyu Won Kim, Bon Hong Min

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Clusterin has been reported to be up-regulated in diverse pathophysiological stresses, but its role is controversial. In this study, we investigated the role of clusterin under in vitro ischemia of human retinal endothelial cells (HRECs). When HRECs were exposed to oxygen-glucose deprivation (OGD), clusterin expression increased, whereas von Willebrand factor (vWF), occludin, and zonula occludens (ZO-1) markedly decreased. Interestingly, loss of tight junction proteins and death of HRECs in OGD conditions were restored by clusterin treatment. Our results suggest that the enhanced clusterin in OGD conditions may play a protective role against ischemia-induced tight junction protein loss and HRECs death.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalCurrent Eye Research
Volume32
Issue number7-8
DOIs
Publication statusPublished - 2007 Jul

Keywords

  • Clusterin
  • Endothelial cells
  • Ischemia
  • Protective role
  • Tight junction proteins

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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