The role of Corticotropin-Releasing Factor (CRF) in preclinical models of depression

Research output: Contribution to journalReview article


Corticotropin-releasing factor (CRF) has been implicated in the pathophysiology of depression and anxiety, as it plays a critical role in the neuroendocrine, autonomic, and behavioral responses to stress. Moreover, CRF in the extrahypothalamic area has been closely linked to depression and anxiety. As recent studies have strengthened the view that CRF in the dorsal raphe nucleus and locus ceruleus is involved in preclinical animal models of depression, the recent progress concerning CRF is worthy of review. First, we describe the distribution and function of CRF in brain. Then, we present the role of CRF in preclinical animal models of depression. Further research on CRF and its receptors should help to clarify the pathophysiology of depression and improve the treatment of this debilitating disease.

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalClinical Psychopharmacology and Neuroscience
Issue number2
Publication statusPublished - 2010 Aug 1



  • Anxiety
  • Bed nucleus of the stria terminalis
  • Central nucleus of the amygdala
  • Corticotropin releasing factor
  • Corticotropin releasing factor receptor
  • Depression
  • Dorsal raphe nucleus
  • Locus ceruleus

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Pharmacology (medical)
  • Psychiatry and Mental health

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