The role of critical shear stress on acute coronary syndrome

Jongyoun Kim, Hyemoon Chung, Minhee Cho, Byoung Kwon Lee, Ali Karimi, Sehyun Shin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Increased aggregation of RBC is associated with many vascular diseases, including acute coronary syndrome (ACS). Critical shear-stress (CSS) as in index of red cell aggregation is defined as either the minimum shear-stress required dispersing the aggregates. The objective of this study is to access the role of CSS in ACS comparing to SA, and to evaluate the correlation with usual biomarkers for atherosclerosis such as fibrinogen, hs-CRP. 169 SA and 223 ACS patients were finally enrolled. A detailed medical history and laboratory data were obtained for each participant from clinical records. CSS is measured by simultaneous measurement of shear stress and light backscattering using a small disposable kit with a microfluidic hemorheometer. We hypothesized that higher value of CSS might be associated increased thrombosis in ACS. As results, relatively younger age was shown and more male in ACS patients, and inflammatory markers (WBC, hs-CRP) were higher in ACS. Whole blood viscosities were significantly higher in ACS than SA along at all shear rates. CSS was 25.7% higher in ACS (333.8 ± 147.8) than in SA (265.4 ± 149.9 mPa) (p < 0.001). CSS was highly correlated white blood cell counts, hs-CRP, fibrinogen, and erythrocyte sedimentation rate (ESR). Among those variables, fibrinogen, and ESR were strongly correlated with CSS. We may suggest that CSS could be used as a novel risk marker for ACS.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalClinical Hemorheology and Microcirculation
Volume55
Issue number1
DOIs
Publication statusPublished - 2013 Nov 25

Fingerprint

Acute Coronary Syndrome
Fibrinogen
Blood Sedimentation
Cell Aggregation
Blood Viscosity
Microfluidics
Leukocyte Count
Vascular Diseases
Atherosclerosis
Thrombosis
Biomarkers
Light

Keywords

  • acute coronary syndrome
  • Critical shear stress
  • RBC aggregation

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

The role of critical shear stress on acute coronary syndrome. / Kim, Jongyoun; Chung, Hyemoon; Cho, Minhee; Lee, Byoung Kwon; Karimi, Ali; Shin, Sehyun.

In: Clinical Hemorheology and Microcirculation, Vol. 55, No. 1, 25.11.2013, p. 101-109.

Research output: Contribution to journalArticle

Kim, Jongyoun ; Chung, Hyemoon ; Cho, Minhee ; Lee, Byoung Kwon ; Karimi, Ali ; Shin, Sehyun. / The role of critical shear stress on acute coronary syndrome. In: Clinical Hemorheology and Microcirculation. 2013 ; Vol. 55, No. 1. pp. 101-109.
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