The role of gut-liver axis in the pathogenesis of liver cirrhosis and portal hypertension.

Yeon Seok Seo, Vijay H. Shah

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Because of the anatomical position and its unique vascular system, the liver is susceptible to the exposure to the microbial products from the gut. Although large amount of microbes colonize in the gut, translocation of the microbes or microbial products into the liver and systemic circulation is prevented by gut epithelial barrier function and cleansing and detoxifying functions of the liver in healthy subjects. However, when the intestinal barrier function is disrupted, large amount of bacterial products can enter into the liver and systemic circulation and induce inflammation through their receptors. Nowadays, there have been various reports suggesting the role of gut flora and bacterial translocation in the pathogenesis of chronic liver disease and portal hypertension. This review summarizes the current knowledge about bacterial translocation and its contribution to the pathogenesis of chronic liver diseases and portal hypertension.

Original languageEnglish
Pages (from-to)337-346
Number of pages10
JournalClinical and molecular hepatology
Volume18
Issue number4
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

Fingerprint

Liver Circulation
Bacterial Translocation
Portal Hypertension
Liver Cirrhosis
Liver Diseases
Chronic Disease
Liver
Blood Vessels
Healthy Volunteers
Inflammation
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The role of gut-liver axis in the pathogenesis of liver cirrhosis and portal hypertension. / Seo, Yeon Seok; Shah, Vijay H.

In: Clinical and molecular hepatology, Vol. 18, No. 4, 01.12.2012, p. 337-346.

Research output: Contribution to journalReview article

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