The role of interim 18F-FDG PET/CT in predicting early response to neoadjuvant chemotherapy in breast cancer

Kisoo Pahk, Seunghong Rhee, Jaehyuk Cho, Minhee Seo, Sinae Lee, Taegyu Park, Soyeon Park, Eunsub Lee, Kyung Hwa Park, Chulhan Kim, Jae Seon Eo, Sungeun Kim, Jae Gol Choe

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Aim: The aim of this study was to prove the diagnostic value of interim 18F-Fluorodeoxyglucose-positron-emission tomography combined with computed tomography (PET/CT) scan for predicting pathological complete response (pCR) compared to other factors in neoadjuvant chemotheraphy. Patients and Methods: Twenty-seven patients with breast cancer were included in this retrospective study. They all underwent scheduled neoadjuvant chemotherapy. Patients underwent PET/CT at baseline, mid-point (interim), and preoperatively (after completion of chemotherapy). The metabolic response was calculated as follows: ΔStandardized uptake value (SUV)(%)=(1st SUVmax-2nd SUVmax)/1st SUVmaxx100. Results: The change in SUVmax between baseline and interim PET/CT scans was significantly larger than between interim and preoperative PET/CT scan. An optimal cut-off ΔSUV value of 78.3% was proposed for discriminating patients with pCR from those without pCR. Metabolic CR, defined as a change of SUVmax greater than the cut-off value, can predict pCR according to univariate analysis (p=0.012; Relative risk (RR)=25.3). Furthermore, metabolic CR was the most powerful factor for predicting pCR than other possible factors according to multivariate analysis (p=0.003). Conclusion: It is possible to use interim 18F-FDG PET-CT as an effective method to predict early response in patients with breast cancer treated with neoadjuvant chemotherapy.

Original languageEnglish
Pages (from-to)4447-4456
Number of pages10
JournalAnticancer research
Volume34
Issue number8
Publication statusPublished - 2014 Aug 1

Keywords

  • Breast cancer
  • FDG PET
  • Neoadjuvant chemotherapy
  • PET computed tomographic
  • Response

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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