The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia

Kyoung Sae Na, Han Yong Jung, Yong Ku Kim

Research output: Contribution to journalReview article

151 Citations (Scopus)

Abstract

Schizophrenia is a serious mental illness with chronic symptoms and significant impairment in psychosocial functioning. Although novel antipsychotics have been developed, the negative and cognitive symptoms of schizophrenia are still unresponsive to pharmacotherapy. The high level of social impairment and a chronic deteriorating course suggest that schizophrenia likely has neurodegenerative characteristics.Inflammatory markers such as pro-inflammatory cytokines are well-known etiological factors for psychiatric disorders, including schizophrenia. Inflammation in the central nervous system is closely related to neurodegeneration. In addition to pro-inflammatory cytokines, microglia also play an important role in the inflammatory process in the CNS. Uncontrolled activity of pro-inflammatory cytokines and microglia can induce schizophrenia in tandem with genetic vulnerability and glutamatergic neurotransmitters. Several studies have investigated the possible effects of antipsychotics on inflammation and neurogenesis. Additionally, anti-inflammatory adjuvant therapy has been under investigation as a treatment option for schizophrenia. Further studies should consider the confounding effects of systemic factors such as metabolic syndrome and smoking. In addition, the unique mechanisms by which pro-inflammatory cytokines are involved in the etiopathology of schizophrenia should be investigated. In this article, we aimed to review (1) major findings regarding neuroinflammation and pro-inflammatory cytokine alterations in schizophrenia, (2) interactions between neuroinflammation and neurogenesis as possible neural substrates for schizophrenia, and (3) novel pharmacological approaches.

Original languageEnglish
Pages (from-to)277-286
Number of pages10
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume48
DOIs
Publication statusPublished - 2014 Jan 3

Fingerprint

Neurogenesis
Schizophrenia
Cytokines
Microglia
Antipsychotic Agents
Inflammation
Neurobehavioral Manifestations
Neurotransmitter Agents
Psychiatry
Chronic Disease
Anti-Inflammatory Agents
Central Nervous System
Smoking
Pharmacology
Drug Therapy
Therapeutics

Keywords

  • Cytokine
  • Neurodegeneration
  • Neurogenesis
  • Neuroinflammation
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia. / Na, Kyoung Sae; Jung, Han Yong; Kim, Yong Ku.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 48, 03.01.2014, p. 277-286.

Research output: Contribution to journalReview article

@article{e5ede49dca3042b490e7da78620f040a,
title = "The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia",
abstract = "Schizophrenia is a serious mental illness with chronic symptoms and significant impairment in psychosocial functioning. Although novel antipsychotics have been developed, the negative and cognitive symptoms of schizophrenia are still unresponsive to pharmacotherapy. The high level of social impairment and a chronic deteriorating course suggest that schizophrenia likely has neurodegenerative characteristics.Inflammatory markers such as pro-inflammatory cytokines are well-known etiological factors for psychiatric disorders, including schizophrenia. Inflammation in the central nervous system is closely related to neurodegeneration. In addition to pro-inflammatory cytokines, microglia also play an important role in the inflammatory process in the CNS. Uncontrolled activity of pro-inflammatory cytokines and microglia can induce schizophrenia in tandem with genetic vulnerability and glutamatergic neurotransmitters. Several studies have investigated the possible effects of antipsychotics on inflammation and neurogenesis. Additionally, anti-inflammatory adjuvant therapy has been under investigation as a treatment option for schizophrenia. Further studies should consider the confounding effects of systemic factors such as metabolic syndrome and smoking. In addition, the unique mechanisms by which pro-inflammatory cytokines are involved in the etiopathology of schizophrenia should be investigated. In this article, we aimed to review (1) major findings regarding neuroinflammation and pro-inflammatory cytokine alterations in schizophrenia, (2) interactions between neuroinflammation and neurogenesis as possible neural substrates for schizophrenia, and (3) novel pharmacological approaches.",
keywords = "Cytokine, Neurodegeneration, Neurogenesis, Neuroinflammation, Schizophrenia",
author = "Na, {Kyoung Sae} and Jung, {Han Yong} and Kim, {Yong Ku}",
year = "2014",
month = "1",
day = "3",
doi = "10.1016/j.pnpbp.2012.10.022",
language = "English",
volume = "48",
pages = "277--286",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - The role of pro-inflammatory cytokines in the neuroinflammation and neurogenesis of schizophrenia

AU - Na, Kyoung Sae

AU - Jung, Han Yong

AU - Kim, Yong Ku

PY - 2014/1/3

Y1 - 2014/1/3

N2 - Schizophrenia is a serious mental illness with chronic symptoms and significant impairment in psychosocial functioning. Although novel antipsychotics have been developed, the negative and cognitive symptoms of schizophrenia are still unresponsive to pharmacotherapy. The high level of social impairment and a chronic deteriorating course suggest that schizophrenia likely has neurodegenerative characteristics.Inflammatory markers such as pro-inflammatory cytokines are well-known etiological factors for psychiatric disorders, including schizophrenia. Inflammation in the central nervous system is closely related to neurodegeneration. In addition to pro-inflammatory cytokines, microglia also play an important role in the inflammatory process in the CNS. Uncontrolled activity of pro-inflammatory cytokines and microglia can induce schizophrenia in tandem with genetic vulnerability and glutamatergic neurotransmitters. Several studies have investigated the possible effects of antipsychotics on inflammation and neurogenesis. Additionally, anti-inflammatory adjuvant therapy has been under investigation as a treatment option for schizophrenia. Further studies should consider the confounding effects of systemic factors such as metabolic syndrome and smoking. In addition, the unique mechanisms by which pro-inflammatory cytokines are involved in the etiopathology of schizophrenia should be investigated. In this article, we aimed to review (1) major findings regarding neuroinflammation and pro-inflammatory cytokine alterations in schizophrenia, (2) interactions between neuroinflammation and neurogenesis as possible neural substrates for schizophrenia, and (3) novel pharmacological approaches.

AB - Schizophrenia is a serious mental illness with chronic symptoms and significant impairment in psychosocial functioning. Although novel antipsychotics have been developed, the negative and cognitive symptoms of schizophrenia are still unresponsive to pharmacotherapy. The high level of social impairment and a chronic deteriorating course suggest that schizophrenia likely has neurodegenerative characteristics.Inflammatory markers such as pro-inflammatory cytokines are well-known etiological factors for psychiatric disorders, including schizophrenia. Inflammation in the central nervous system is closely related to neurodegeneration. In addition to pro-inflammatory cytokines, microglia also play an important role in the inflammatory process in the CNS. Uncontrolled activity of pro-inflammatory cytokines and microglia can induce schizophrenia in tandem with genetic vulnerability and glutamatergic neurotransmitters. Several studies have investigated the possible effects of antipsychotics on inflammation and neurogenesis. Additionally, anti-inflammatory adjuvant therapy has been under investigation as a treatment option for schizophrenia. Further studies should consider the confounding effects of systemic factors such as metabolic syndrome and smoking. In addition, the unique mechanisms by which pro-inflammatory cytokines are involved in the etiopathology of schizophrenia should be investigated. In this article, we aimed to review (1) major findings regarding neuroinflammation and pro-inflammatory cytokine alterations in schizophrenia, (2) interactions between neuroinflammation and neurogenesis as possible neural substrates for schizophrenia, and (3) novel pharmacological approaches.

KW - Cytokine

KW - Neurodegeneration

KW - Neurogenesis

KW - Neuroinflammation

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84888883580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888883580&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2012.10.022

DO - 10.1016/j.pnpbp.2012.10.022

M3 - Review article

C2 - 23123365

AN - SCOPUS:84888883580

VL - 48

SP - 277

EP - 286

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

ER -