The role of spinal and peripheral α1- and α2-adrenoceptors on bladder activity induced by bladder distension in anaesthetized rat

M. S. Jeong, Jeong Gu Lee

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective. To elucidate the effects of α1- and α2-adrenoceptor antagonists on the micturition reflex induced by bladder distension in the anaesthetized rat at the peripheral and spinal level. Materials and methods. Using continuous cystometry in 80 anaesthetized female Sprague-Dawley rats, changes in basal pressure (BaP), micturition pressure (MP), bladder capacity (BC), micturition volume (MV), interval of bladder contraction (frequency) and residual volume (RV) to the selective intra-arterial and intrathecal administration of drugs were monitored and analysed. Results. The intra-arterial administration of phentolamine, prazosin, doxazosin and tamsulosin significantly decreased the MP; doxazosin increased MV, BC, RV and frequency. MP was inhibited more by intra-arterial doxazosin than by prazosin or tamsulosin. Intrathecal phentolamine increased BaP, BC, RV and decreased MP and MV; tamsulosin decreased frequency and increased BC. Clonidine markedly increased BaP and frequency, whereas MV; and BC were significantly lower; yohimbine increased MV. BC and decreased RV. Intra-arterial yohimbine significantly increased MV. Conclusions. At the spinal level, the micturition reflex evoked by bladder distension was preferentially suppressed by phentolamine or yohimbine, suggesting the involvement of α2-adrenoceptors. In the periphery, α1-adrenoceptor blockers preferentially suppressed the reflex. We suggest that both α1- and α2-adrenoceptors play a role in the distension-evoked micturition reflex in the rat.

Original languageEnglish
Pages (from-to)925-931
Number of pages7
JournalBJU International
Volume85
Issue number7
DOIs
Publication statusPublished - 2000 May 17

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Urination
Adrenergic Receptors
Urinary Bladder
tamsulosin
Residual Volume
Pressure
Doxazosin
Yohimbine
Reflex
Phentolamine
Prazosin
Clonidine
Sprague Dawley Rats

Keywords

  • Micturition α-adrenoceptor
  • Rat
  • Spinal cord

ASJC Scopus subject areas

  • Urology

Cite this

The role of spinal and peripheral α1- and α2-adrenoceptors on bladder activity induced by bladder distension in anaesthetized rat. / Jeong, M. S.; Lee, Jeong Gu.

In: BJU International, Vol. 85, No. 7, 17.05.2000, p. 925-931.

Research output: Contribution to journalArticle

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N2 - Objective. To elucidate the effects of α1- and α2-adrenoceptor antagonists on the micturition reflex induced by bladder distension in the anaesthetized rat at the peripheral and spinal level. Materials and methods. Using continuous cystometry in 80 anaesthetized female Sprague-Dawley rats, changes in basal pressure (BaP), micturition pressure (MP), bladder capacity (BC), micturition volume (MV), interval of bladder contraction (frequency) and residual volume (RV) to the selective intra-arterial and intrathecal administration of drugs were monitored and analysed. Results. The intra-arterial administration of phentolamine, prazosin, doxazosin and tamsulosin significantly decreased the MP; doxazosin increased MV, BC, RV and frequency. MP was inhibited more by intra-arterial doxazosin than by prazosin or tamsulosin. Intrathecal phentolamine increased BaP, BC, RV and decreased MP and MV; tamsulosin decreased frequency and increased BC. Clonidine markedly increased BaP and frequency, whereas MV; and BC were significantly lower; yohimbine increased MV. BC and decreased RV. Intra-arterial yohimbine significantly increased MV. Conclusions. At the spinal level, the micturition reflex evoked by bladder distension was preferentially suppressed by phentolamine or yohimbine, suggesting the involvement of α2-adrenoceptors. In the periphery, α1-adrenoceptor blockers preferentially suppressed the reflex. We suggest that both α1- and α2-adrenoceptors play a role in the distension-evoked micturition reflex in the rat.

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