The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

Hak Jun Kim, Sun Woong Kang, Hong Chul Lim, Seung Bum Han, Jae Sun Lee, Leela Prasad, Yoon Jung Kim, Byung Soo Kim, Jung Ho Park

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)

    Abstract

    Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

    Original languageEnglish
    Pages (from-to)309-315
    Number of pages7
    JournalConnective Tissue Research
    Volume48
    Issue number6
    DOIs
    Publication statusPublished - 2007 Nov

    Keywords

    • Achilles tendon
    • Bone morphogenetic protein
    • Bone-tendon junction
    • Fibrin glue
    • Transforming growth factor-β

    ASJC Scopus subject areas

    • Rheumatology
    • Biochemistry
    • Orthopedics and Sports Medicine
    • Molecular Biology
    • Cell Biology

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