The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

Hak Jun Kim, Sun Woong Kang, Hong Chul Lim, Seung Bum Han, Jae Sun Lee, Leela Prasad, Yoon Jung Kim, Byung Soo Kim, Jung-Ho Park

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalConnective Tissue Research
Volume48
Issue number6
DOIs
Publication statusPublished - 2007 Nov 1

Fingerprint

Tendon Injuries
Fibrin Tissue Adhesive
Bone Morphogenetic Proteins
Tendons
Transforming Growth Factors
Bone
Bone and Bones
Repair
Tissue
Sutures
Animals
Rabbits
Wounds and Injuries

Keywords

  • Achilles tendon
  • Bone morphogenetic protein
  • Bone-tendon junction
  • Fibrin glue
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Nephrology
  • Cell Biology
  • Orthopedics and Sports Medicine

Cite this

The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury. / Kim, Hak Jun; Kang, Sun Woong; Lim, Hong Chul; Han, Seung Bum; Lee, Jae Sun; Prasad, Leela; Kim, Yoon Jung; Kim, Byung Soo; Park, Jung-Ho.

In: Connective Tissue Research, Vol. 48, No. 6, 01.11.2007, p. 309-315.

Research output: Contribution to journalArticle

Kim, Hak Jun ; Kang, Sun Woong ; Lim, Hong Chul ; Han, Seung Bum ; Lee, Jae Sun ; Prasad, Leela ; Kim, Yoon Jung ; Kim, Byung Soo ; Park, Jung-Ho. / The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury. In: Connective Tissue Research. 2007 ; Vol. 48, No. 6. pp. 309-315.
@article{e16b941fbacd4f989f6f6352d0b53df0,
title = "The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury",
abstract = "Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.",
keywords = "Achilles tendon, Bone morphogenetic protein, Bone-tendon junction, Fibrin glue, Transforming growth factor-β",
author = "Kim, {Hak Jun} and Kang, {Sun Woong} and Lim, {Hong Chul} and Han, {Seung Bum} and Lee, {Jae Sun} and Leela Prasad and Kim, {Yoon Jung} and Kim, {Byung Soo} and Jung-Ho Park",
year = "2007",
month = "11",
day = "1",
doi = "10.1080/03008200701692610",
language = "English",
volume = "48",
pages = "309--315",
journal = "Connective Tissue Research",
issn = "0300-8207",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

AU - Kim, Hak Jun

AU - Kang, Sun Woong

AU - Lim, Hong Chul

AU - Han, Seung Bum

AU - Lee, Jae Sun

AU - Prasad, Leela

AU - Kim, Yoon Jung

AU - Kim, Byung Soo

AU - Park, Jung-Ho

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

AB - Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

KW - Achilles tendon

KW - Bone morphogenetic protein

KW - Bone-tendon junction

KW - Fibrin glue

KW - Transforming growth factor-β

UR - http://www.scopus.com/inward/record.url?scp=37349001266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37349001266&partnerID=8YFLogxK

U2 - 10.1080/03008200701692610

DO - 10.1080/03008200701692610

M3 - Article

VL - 48

SP - 309

EP - 315

JO - Connective Tissue Research

JF - Connective Tissue Research

SN - 0300-8207

IS - 6

ER -