The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

Hak Jun Kim; Sun Woong Kang; Hong Chul Lim; Seung Bum Han; Jae Sun Lee; Leela Prasad; Yoon Jung Kim; Byung Soo Kim; Jung-Ho Park

doi:10.1080/03008200701692610

The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

Hak Jun Kim, Sun Woong Kang, Hong Chul Lim, Seung Bum Han, Jae Sun Lee, Leela Prasad, Yoon Jung Kim, Byung Soo Kim, Jung-Ho Park

Department of Orthopedic Surgery

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

Original language	English
Pages (from-to)	309-315
Number of pages	7
Journal	Connective Tissue Research
Volume	48
Issue number	6
DOIs	https://doi.org/10.1080/03008200701692610
Publication status	Published - 2007 Nov 1

Keywords

Achilles tendon
Bone morphogenetic protein
Bone-tendon junction
Fibrin glue
Transforming growth factor-β

ASJC Scopus subject areas

Biochemistry
Immunology
Nephrology
Cell Biology
Orthopedics and Sports Medicine

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Kim, H. J., Kang, S. W., Lim, H. C., Han, S. B., Lee, J. S., Prasad, L., Kim, Y. J., Kim, B. S., & Park, J-H. (2007). The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury. Connective Tissue Research, 48(6), 309-315. https://doi.org/10.1080/03008200701692610

The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury. / Kim, Hak Jun; Kang, Sun Woong; Lim, Hong Chul; Han, Seung Bum; Lee, Jae Sun; Prasad, Leela; Kim, Yoon Jung; Kim, Byung Soo; Park, Jung-Ho.

In: Connective Tissue Research, Vol. 48, No. 6, 01.11.2007, p. 309-315.

Research output: Contribution to journal › Article

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