Abstract
Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.
| Original language | English |
|---|---|
| Pages (from-to) | 309-315 |
| Number of pages | 7 |
| Journal | Connective Tissue Research |
| Volume | 48 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2007 Nov 1 |
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Keywords
- Achilles tendon
- Bone morphogenetic protein
- Bone-tendon junction
- Fibrin glue
- Transforming growth factor-β
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Nephrology
- Cell Biology
- Orthopedics and Sports Medicine
Cite this
The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury. / Kim, Hak Jun; Kang, Sun Woong; Lim, Hong Chul; Han, Seung Bum; Lee, Jae Sun; Prasad, Leela; Kim, Yoon Jung; Kim, Byung Soo; Park, Jung-Ho.
In: Connective Tissue Research, Vol. 48, No. 6, 01.11.2007, p. 309-315.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury
AU - Kim, Hak Jun
AU - Kang, Sun Woong
AU - Lim, Hong Chul
AU - Han, Seung Bum
AU - Lee, Jae Sun
AU - Prasad, Leela
AU - Kim, Yoon Jung
AU - Kim, Byung Soo
AU - Park, Jung-Ho
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.
AB - Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.
KW - Achilles tendon
KW - Bone morphogenetic protein
KW - Bone-tendon junction
KW - Fibrin glue
KW - Transforming growth factor-β
UR - http://www.scopus.com/inward/record.url?scp=37349001266&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37349001266&partnerID=8YFLogxK
U2 - 10.1080/03008200701692610
DO - 10.1080/03008200701692610
M3 - Article
C2 - 18075817
AN - SCOPUS:37349001266
VL - 48
SP - 309
EP - 315
JO - Connective Tissue Research
JF - Connective Tissue Research
SN - 0300-8207
IS - 6
ER -