Abstract
Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.
Original language | English |
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Pages (from-to) | 309-315 |
Number of pages | 7 |
Journal | Connective Tissue Research |
Volume | 48 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2007 Nov |
Keywords
- Achilles tendon
- Bone morphogenetic protein
- Bone-tendon junction
- Fibrin glue
- Transforming growth factor-β
ASJC Scopus subject areas
- Rheumatology
- Biochemistry
- Orthopedics and Sports Medicine
- Molecular Biology
- Cell Biology