The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

Hak Jun Kim; Sun Woong Kang; Hong Chul Lim; Seung Bum Han; Jae Sun Lee; Leela Prasad; Yoon Jung Kim; Byung Soo Kim; Jung Ho Park

doi:10.1080/03008200701692610

The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

Hak Jun Kim, Sun Woong Kang, Hong Chul Lim, Seung Bum Han, Jae Sun Lee, Leela Prasad, Yoon Jung Kim, Byung Soo Kim, Jung Ho Park

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

Original language	English
Pages (from-to)	309-315
Number of pages	7
Journal	Connective Tissue Research
Volume	48
Issue number	6
DOIs	https://doi.org/10.1080/03008200701692610
Publication status	Published - 2007 Nov

Keywords

Achilles tendon
Bone morphogenetic protein
Bone-tendon junction
Fibrin glue
Transforming growth factor-β

ASJC Scopus subject areas

Rheumatology
Biochemistry
Orthopedics and Sports Medicine
Molecular Biology
Cell Biology

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10.1080/03008200701692610

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title = "The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury",

abstract = "Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.",

keywords = "Achilles tendon, Bone morphogenetic protein, Bone-tendon junction, Fibrin glue, Transforming growth factor-β",

author = "Kim, {Hak Jun} and Kang, {Sun Woong} and Lim, {Hong Chul} and Han, {Seung Bum} and Lee, {Jae Sun} and Leela Prasad and Kim, {Yoon Jung} and Kim, {Byung Soo} and Park, {Jung Ho}",

note = "Funding Information: This work was supported by a grant (SC 3220) from the Stem Cell Research Center of the 21st Century Frontier Program funded by the Ministry of Science and Technology, Republic of Korea.",

year = "2007",

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doi = "10.1080/03008200701692610",

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journal = "Connective Tissue Research",

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AU - Kim, Hak Jun

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AU - Lim, Hong Chul

AU - Han, Seung Bum

AU - Lee, Jae Sun

AU - Prasad, Leela

AU - Kim, Yoon Jung

AU - Kim, Byung Soo

AU - Park, Jung Ho

N1 - Funding Information: This work was supported by a grant (SC 3220) from the Stem Cell Research Center of the 21st Century Frontier Program funded by the Ministry of Science and Technology, Republic of Korea.

PY - 2007/11

Y1 - 2007/11

N2 - Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

AB - Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

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The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

Abstract

Keywords

ASJC Scopus subject areas

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