The role of transforming growth factor-β and bone morphogenetic protein with fibrin glue in healing of bone-tendon junction injury

Hak Jun Kim, Sun Woong Kang, Hong Chul Lim, Seung Bum Han, Jae Sun Lee, Leela Prasad, Yoon Jung Kim, Byung Soo Kim, Jung-Ho Park

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Bone-tendon junction injuries have poor healing potential. This study evaluated the role of TGF-β and BMP-2 in a fibrin glue carrier in healing of injuries at bone-tendon junction. Seventy-two skeletally mature male rabbits were divided into 4 groups. The tendo-Achilles was surgically transected at its insertion and reattached with a pullout suture. Group 1 served as a control. In groups 2, 3, and 4, fibrin glue, a mixture of TGF-β and fibrin glue, and a mixture of BMP-2 and fibrin glue were injected into the bone-tendon junction. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The addition of TGF-β to fibrin glue did not significantly improve the biomechanical properties of repair tissue. BMP-2 in combination with fibrin glue accelerates healing in a bone-tendon injury and also improves the histological and biomechanical properties of the repair tissue so formed.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalConnective Tissue Research
Volume48
Issue number6
DOIs
Publication statusPublished - 2007 Nov 1

Keywords

  • Achilles tendon
  • Bone morphogenetic protein
  • Bone-tendon junction
  • Fibrin glue
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Nephrology
  • Cell Biology
  • Orthopedics and Sports Medicine

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