The role of urinary liver-type fatty acid-binding protein in critically ill patients

Eunjung Cho, Ha Na Yang, Sang Kyung Jo, Won Yong Cho, Hyoung Kyu Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Although several urinary biomarkers have been validated as early diagnostic markers of acute kidney injury (AKI), their usefulness as outcome predictors is not well established. This study aimed to determine the diagnostic and prognostic abilities of urinary liver-type fatty acid-binding protein (L-FABP) in heterogeneous critically ill patients. We prospectively collected data on patients admitted to medical and surgical intensive care units (ICUs) from July 2010 to June 2011. Urine neutrophil gelatinase-associated lipocalin (NGAL) and L-FABP at the time of ICU admission were quantitated. Of the 145 patients, 54 (37.2%) had AKI defined by the Acute Kidney Injury Network (AKIN) criteria. AKI patients showed significantly higher level of urinary NGAL and L-FABP and also higher mortality than non-AKI patients. The diagnostic performances, assessed by the area under the ROC curve, were 0.773 for NGAL and 0.780 for L-FABP, demonstrating their usefulness in diagnosing AKI. In multivariate Cox analysis, urinary L-FABP was an independent predictor for 90-day mortality. Urinary L-FABP seems to be promising both for the diagnosis of AKI and for the prediction of prognosis in heterogeneous ICU patients. It needs to be further validated for clinical utility.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalJournal of Korean Medical Science
Volume28
Issue number1
DOIs
Publication statusPublished - 2013 Mar 13

Fingerprint

Fatty Acid-Binding Proteins
Acute Kidney Injury
Critical Illness
Intensive Care Units
Mortality
Critical Care
ROC Curve
Area Under Curve
Multivariate Analysis
Biomarkers
Urine
Kidney
Wounds and Injuries
Lipocalin-2

Keywords

  • Acute kidney injury
  • Liver-type fatty acid-binding protein
  • Neutrophil gelatinase-associated lipocalin
  • Prognosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The role of urinary liver-type fatty acid-binding protein in critically ill patients. / Cho, Eunjung; Yang, Ha Na; Jo, Sang Kyung; Cho, Won Yong; Kim, Hyoung Kyu.

In: Journal of Korean Medical Science, Vol. 28, No. 1, 13.03.2013, p. 100-105.

Research output: Contribution to journalArticle

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