The roles of PDZ-containing proteins in PLC-β-mediated signaling

Pann Ghill Suh, Jong Ik Hwang, Sung Ho Ryu, Mark Donowitz, Jae Ho Kim

Research output: Contribution to journalReview article

70 Citations (Scopus)

Abstract

Mammalian phospholipase C-β isozymes are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Recent reports suggest that PDZ domain proteins play a significant role of PDZ-containing proteins in the regulation of mammalian PLC-β isozymes. PDZ-containing proteins mediate the clustering of receptors and signaling molecules and thereby regulate agonist-induced signal transduction in polarized cells such as neuronal and epithelial cells NORPA, a Drosophila PLC-β, is known to be a component of a signaling complex that includes TRP and rhodopsin through interaction with INAD, a PDZ-containing protein. Mammalian PLC-β1 and -β2 isoforms interact with a PDZ-containing protein NHERF which is coupled to Trp4, a Ca2+ channel. In addition, PLC-β3 specifically interacts with E3KARP, another protein closely related to NHERF, through its C-terminal PDZ-binding motif. E3KARP up-regulates the PLC-β3 activation coupled to muscarinic receptor. In this review, the role of signaling complexes mediated by PDZ-containing proteins in the regulation of PLC-β isoforms will be discussed.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalBiochemical and biophysical research communications
Volume288
Issue number1
DOIs
Publication statusPublished - 2001 Oct 19
Externally publishedYes

Keywords

  • E3KARP
  • G-protein-coupled receptor
  • INAD
  • NHERF
  • PDZ domain
  • Phospholipase C-β(PLC-β)
  • Trp

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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