The safety and effectiveness of 2-liter polyethylene glycol plus ascorbic acid in patients with liver cirrhosis

Jae Min Lee, Jae Hyung Lee, Eun-Sun Kim, Jung Min Lee, In Kyung Yoo, Seung Han Kim, Hyuk Soon Choi, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Hoon-Jai Chun, Soon-Ho Um, Chang Duck Kim

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1 Citation (Scopus)

Abstract

The safety of bowel-cleansing agents is an important issue in clinical practice, especially in patients with chronic diseases. Although the safety and efficacy of polyethylene glycol (PEG) has been investigated in many studies, few studies on PEG plus ascorbic acid exist. In this study, we compared the safety of 2 bowel-cleansing agents for patients with liver cirrhosis: 2-liter PEG (2L PEG) plus ascorbic acid versus 4-liter PEG (4L PEG). We performed a retrospective study on colonoscopy in patients with liver cirrhosis. Patients referred for colonoscopy were divided into 2 groups: 2L PEG plus ascorbic acid (n=105) and 4L PEG (n=61). Safety was assessed by comparing the clinical factors and laboratory findings as follows: Blood biochemistry, electrolytes, weight change, and bowel-cleansing quality. Serum electrolytes, laboratory findings, and body weight showed no significant change between the 2 groups. There was no significant change in clinical factors before and after bowel preparation in the PEG group or the PEG plus ascorbic acid group. The acceptability and compliance of patients was better in the 2L PEG plus ascorbic acid than the 4L PEG group. In subgroup analysis, patients with compensated or decompensated cirrhosis showed no increased risk of electrolyte imbalances after bowel preparation. Child-Pugh scores did not influence the outcome after bowel cleansing. Successful cleansing was mostly achieved in both groups. Our analysis showed that of the use of 2L PEG plus ascorbic acid could be a safe choice for colonoscopy in patients with liver cirrhosis.

Original languageEnglish
Article numbere9011
JournalMedicine (United States)
Volume96
Issue number51
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Liver Cirrhosis
Ascorbic Acid
Safety
Colonoscopy
Electrolytes
Detergents
Patient Compliance
Biochemistry
Fibrosis
Chronic Disease
Retrospective Studies
Body Weight
Weights and Measures
Serum

Keywords

  • ascorbic acid
  • colonoscopy
  • liver cirrhosis
  • polyethylene glycol
  • safety

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "The safety and effectiveness of 2-liter polyethylene glycol plus ascorbic acid in patients with liver cirrhosis",
abstract = "The safety of bowel-cleansing agents is an important issue in clinical practice, especially in patients with chronic diseases. Although the safety and efficacy of polyethylene glycol (PEG) has been investigated in many studies, few studies on PEG plus ascorbic acid exist. In this study, we compared the safety of 2 bowel-cleansing agents for patients with liver cirrhosis: 2-liter PEG (2L PEG) plus ascorbic acid versus 4-liter PEG (4L PEG). We performed a retrospective study on colonoscopy in patients with liver cirrhosis. Patients referred for colonoscopy were divided into 2 groups: 2L PEG plus ascorbic acid (n=105) and 4L PEG (n=61). Safety was assessed by comparing the clinical factors and laboratory findings as follows: Blood biochemistry, electrolytes, weight change, and bowel-cleansing quality. Serum electrolytes, laboratory findings, and body weight showed no significant change between the 2 groups. There was no significant change in clinical factors before and after bowel preparation in the PEG group or the PEG plus ascorbic acid group. The acceptability and compliance of patients was better in the 2L PEG plus ascorbic acid than the 4L PEG group. In subgroup analysis, patients with compensated or decompensated cirrhosis showed no increased risk of electrolyte imbalances after bowel preparation. Child-Pugh scores did not influence the outcome after bowel cleansing. Successful cleansing was mostly achieved in both groups. Our analysis showed that of the use of 2L PEG plus ascorbic acid could be a safe choice for colonoscopy in patients with liver cirrhosis.",
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AU - Lee, Jae Hyung

AU - Kim, Eun-Sun

AU - Lee, Jung Min

AU - Yoo, In Kyung

AU - Kim, Seung Han

AU - Choi, Hyuk Soon

AU - Keum, Bora

AU - Seo, Yeon Seok

AU - Jeen, Yoon Tae

AU - Lee, Hong Sik

AU - Chun, Hoon-Jai

AU - Um, Soon-Ho

AU - Kim, Chang Duck

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AB - The safety of bowel-cleansing agents is an important issue in clinical practice, especially in patients with chronic diseases. Although the safety and efficacy of polyethylene glycol (PEG) has been investigated in many studies, few studies on PEG plus ascorbic acid exist. In this study, we compared the safety of 2 bowel-cleansing agents for patients with liver cirrhosis: 2-liter PEG (2L PEG) plus ascorbic acid versus 4-liter PEG (4L PEG). We performed a retrospective study on colonoscopy in patients with liver cirrhosis. Patients referred for colonoscopy were divided into 2 groups: 2L PEG plus ascorbic acid (n=105) and 4L PEG (n=61). Safety was assessed by comparing the clinical factors and laboratory findings as follows: Blood biochemistry, electrolytes, weight change, and bowel-cleansing quality. Serum electrolytes, laboratory findings, and body weight showed no significant change between the 2 groups. There was no significant change in clinical factors before and after bowel preparation in the PEG group or the PEG plus ascorbic acid group. The acceptability and compliance of patients was better in the 2L PEG plus ascorbic acid than the 4L PEG group. In subgroup analysis, patients with compensated or decompensated cirrhosis showed no increased risk of electrolyte imbalances after bowel preparation. Child-Pugh scores did not influence the outcome after bowel cleansing. Successful cleansing was mostly achieved in both groups. Our analysis showed that of the use of 2L PEG plus ascorbic acid could be a safe choice for colonoscopy in patients with liver cirrhosis.

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