The scope and limitation of nickel-catalyzed aminocarbonylation of aryl bromides from formamide derivatives

Youngshin Jo, Jinhun Ju, Jaehoon Choe, Ho Song Kwang, Sunwoo Lee

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

(Chemical Equation Presented) Nickel-catalyzed aminocarbonylation of aryl halides is described. A well-defined air-stable nickel-phosphite catalytic system (Ni(OAc)2 · 4H2O/phosphite 1) effectively promoted the aminocarbonylation of aryl bromides with a range of formamides to give the corresponding aryl amide products in moderate to good yields. The less hindered formamide required lower catalytic loading for full conversion and produced higher yields than the more hindered one. It also exhibited base-dependent activity toward formamides.

Original languageEnglish
Pages (from-to)6358-6361
Number of pages4
JournalJournal of Organic Chemistry
Volume74
Issue number16
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Organic Chemistry

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