The sequential change of MRI signal intensity in normal liver after radiotherapy for hepatocellular carcinoma

Research output: Contribution to journalArticle

Abstract

To differentiate the interval change of irradiated normal liver from other pathologic status, our study observed early and late MRI signal changes based on radiation dose distribution in normal liver after three-dimensional conformal radiotherapy. We retrospectively evaluated 21 patients with hepatocellular carcinoma who received 40 Gy/16 fractions or 54 Gy/27 fractions radiotherapy of curative aim. The early and late terms were defined as 2 to 4 months and 10 to 14 months after radiotherapy, respectively. The simulation CT, follow-up MRI, and information regarding dose distribution were fused using the deformable registration technique. We evaluated various MRI image sets after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid enhancement. The five regions of interest were drawn according to radiation dose distribution (Vx: The volume corresponding to the range of total irradiation dose; V>90%, V60-90%, V30-60%, V5-30%, and V<5%), and an ANOVA test was performed to compare signal differences between regions. We analyzed 19 and 11 cases of early and late term MRIs, respectively. In the early and late term, the V>90% of hepatobiliary phase images (p < 0.001 and p = 0.005, respectively) and T2-weighted images (p = 0.048 and p <0.001, respectively) were stratified with other regions showing the low and high signal, respectively. High radiation dose with curative intent can affect MRI signals on hepatobiliary phase and T2-weighted images.

Original languageEnglish
Pages (from-to)731-738
Number of pages8
JournalJournal of Medical Imaging and Health Informatics
Volume6
Issue number3
DOIs
Publication statusPublished - 2016 Jun 1

Fingerprint

Hepatocellular Carcinoma
Radiotherapy
Radiation
Liver
Conformal Radiotherapy
Normal Distribution
gadolinium ethoxybenzyl DTPA

Keywords

  • Deformable registration
  • Dose distribution
  • Hepatocellular carcinoma
  • MRI
  • Radiotherapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Health Informatics

Cite this

@article{aad4d4bd6f0f4c5997c5af4b0939f458,
title = "The sequential change of MRI signal intensity in normal liver after radiotherapy for hepatocellular carcinoma",
abstract = "To differentiate the interval change of irradiated normal liver from other pathologic status, our study observed early and late MRI signal changes based on radiation dose distribution in normal liver after three-dimensional conformal radiotherapy. We retrospectively evaluated 21 patients with hepatocellular carcinoma who received 40 Gy/16 fractions or 54 Gy/27 fractions radiotherapy of curative aim. The early and late terms were defined as 2 to 4 months and 10 to 14 months after radiotherapy, respectively. The simulation CT, follow-up MRI, and information regarding dose distribution were fused using the deformable registration technique. We evaluated various MRI image sets after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid enhancement. The five regions of interest were drawn according to radiation dose distribution (Vx: The volume corresponding to the range of total irradiation dose; V>90{\%}, V60-90{\%}, V30-60{\%}, V5-30{\%}, and V<5{\%}), and an ANOVA test was performed to compare signal differences between regions. We analyzed 19 and 11 cases of early and late term MRIs, respectively. In the early and late term, the V>90{\%} of hepatobiliary phase images (p < 0.001 and p = 0.005, respectively) and T2-weighted images (p = 0.048 and p <0.001, respectively) were stratified with other regions showing the low and high signal, respectively. High radiation dose with curative intent can affect MRI signals on hepatobiliary phase and T2-weighted images.",
keywords = "Deformable registration, Dose distribution, Hepatocellular carcinoma, MRI, Radiotherapy",
author = "Lee, {Nam Kwon} and Yoon, {Won Sup} and Lee, {Jung Ae} and Suk Lee and Dae-Sik Yang and Kim, {Chul Yong} and Suh, {Sang Jun} and Yim, {Hyung Joon} and Yeom, {Suk Keu} and Chung, {Hwan Hoon}",
year = "2016",
month = "6",
day = "1",
doi = "10.1166/jmihi.2016.1739",
language = "English",
volume = "6",
pages = "731--738",
journal = "Journal of Medical Imaging and Health Informatics",
issn = "2156-7018",
publisher = "American Scientific Publishers",
number = "3",

}

TY - JOUR

T1 - The sequential change of MRI signal intensity in normal liver after radiotherapy for hepatocellular carcinoma

AU - Lee, Nam Kwon

AU - Yoon, Won Sup

AU - Lee, Jung Ae

AU - Lee, Suk

AU - Yang, Dae-Sik

AU - Kim, Chul Yong

AU - Suh, Sang Jun

AU - Yim, Hyung Joon

AU - Yeom, Suk Keu

AU - Chung, Hwan Hoon

PY - 2016/6/1

Y1 - 2016/6/1

N2 - To differentiate the interval change of irradiated normal liver from other pathologic status, our study observed early and late MRI signal changes based on radiation dose distribution in normal liver after three-dimensional conformal radiotherapy. We retrospectively evaluated 21 patients with hepatocellular carcinoma who received 40 Gy/16 fractions or 54 Gy/27 fractions radiotherapy of curative aim. The early and late terms were defined as 2 to 4 months and 10 to 14 months after radiotherapy, respectively. The simulation CT, follow-up MRI, and information regarding dose distribution were fused using the deformable registration technique. We evaluated various MRI image sets after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid enhancement. The five regions of interest were drawn according to radiation dose distribution (Vx: The volume corresponding to the range of total irradiation dose; V>90%, V60-90%, V30-60%, V5-30%, and V<5%), and an ANOVA test was performed to compare signal differences between regions. We analyzed 19 and 11 cases of early and late term MRIs, respectively. In the early and late term, the V>90% of hepatobiliary phase images (p < 0.001 and p = 0.005, respectively) and T2-weighted images (p = 0.048 and p <0.001, respectively) were stratified with other regions showing the low and high signal, respectively. High radiation dose with curative intent can affect MRI signals on hepatobiliary phase and T2-weighted images.

AB - To differentiate the interval change of irradiated normal liver from other pathologic status, our study observed early and late MRI signal changes based on radiation dose distribution in normal liver after three-dimensional conformal radiotherapy. We retrospectively evaluated 21 patients with hepatocellular carcinoma who received 40 Gy/16 fractions or 54 Gy/27 fractions radiotherapy of curative aim. The early and late terms were defined as 2 to 4 months and 10 to 14 months after radiotherapy, respectively. The simulation CT, follow-up MRI, and information regarding dose distribution were fused using the deformable registration technique. We evaluated various MRI image sets after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid enhancement. The five regions of interest were drawn according to radiation dose distribution (Vx: The volume corresponding to the range of total irradiation dose; V>90%, V60-90%, V30-60%, V5-30%, and V<5%), and an ANOVA test was performed to compare signal differences between regions. We analyzed 19 and 11 cases of early and late term MRIs, respectively. In the early and late term, the V>90% of hepatobiliary phase images (p < 0.001 and p = 0.005, respectively) and T2-weighted images (p = 0.048 and p <0.001, respectively) were stratified with other regions showing the low and high signal, respectively. High radiation dose with curative intent can affect MRI signals on hepatobiliary phase and T2-weighted images.

KW - Deformable registration

KW - Dose distribution

KW - Hepatocellular carcinoma

KW - MRI

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=84975705557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975705557&partnerID=8YFLogxK

U2 - 10.1166/jmihi.2016.1739

DO - 10.1166/jmihi.2016.1739

M3 - Article

VL - 6

SP - 731

EP - 738

JO - Journal of Medical Imaging and Health Informatics

JF - Journal of Medical Imaging and Health Informatics

SN - 2156-7018

IS - 3

ER -