The significance of blood pressure variability for the development of hemorrhagic transformation in acute ischemic stroke

Youngchai Ko, Jung Hyun Park, Mi Hwa Yang, Sang Bae Ko, Moon Ku Han, Chang Wan Oh, Jisung Lee, Juneyoung Lee, Hee Joon Bae

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background and Purpose: Elevated blood pressure (BP) is commonly observed in acute ischemic stroke and is known to be associated with hemorrhagic transformation (HT). However, the effect of BP variability on the development of HT is not known well. Methods: A consecutive series of patients with acute ischemic stroke, who were hospitalized within 24 hours of onset and showed no HT on initial gradient echo MRI, were enrolled in this study. BP measurements during the first 72 hours were obtained, and BP variability of each patient was described using various summary parameters: SD, maximum (max), minimum (min), difference between max and min (max-min), average squared difference between successive measurements (sv), and maximum sv (svmax). Results: Of 792 patients meeting the eligibility criteria, 70 (8.8%) developed HT. Among BP variability parameters categorized into quartiles, SBPmax, SBPmin, SBPmax-min, SBPsvmax, DBPSD, DBPmax, DBP min, DBPmax-min, and DBPsvmax were significantly associated with HT independent of mean SBP, age, interval from onset to arrival, initial stroke severity, diabetes mellitus, stroke subtype, thrombolysis, initial glucose, and total cholesterol (P<0.05 on likelihood ratio test of trend). The analyses about the interaction between thrombolysis and variability parameters showed that the effects of BP variability on the development of HT did not differ by whether patients received thrombolysis or not. Conclusions: Our study suggests that we may consider not only the absolute level of BP but also its variability to prevent hemorrhagic transformation.

Original languageEnglish
Pages (from-to)2512-2518
Number of pages7
JournalStroke
Volume41
Issue number11
DOIs
Publication statusPublished - 2010 Nov 1

Fingerprint

Stroke
Blood Pressure
Age of Onset
Diabetes Mellitus
Cholesterol
Glucose

Keywords

  • blood pressure
  • cerebral infarction
  • hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Ko, Y., Park, J. H., Yang, M. H., Ko, S. B., Han, M. K., Oh, C. W., ... Bae, H. J. (2010). The significance of blood pressure variability for the development of hemorrhagic transformation in acute ischemic stroke. Stroke, 41(11), 2512-2518. https://doi.org/10.1161/STROKEAHA.110.595561

The significance of blood pressure variability for the development of hemorrhagic transformation in acute ischemic stroke. / Ko, Youngchai; Park, Jung Hyun; Yang, Mi Hwa; Ko, Sang Bae; Han, Moon Ku; Oh, Chang Wan; Lee, Jisung; Lee, Juneyoung; Bae, Hee Joon.

In: Stroke, Vol. 41, No. 11, 01.11.2010, p. 2512-2518.

Research output: Contribution to journalArticle

Ko, Youngchai ; Park, Jung Hyun ; Yang, Mi Hwa ; Ko, Sang Bae ; Han, Moon Ku ; Oh, Chang Wan ; Lee, Jisung ; Lee, Juneyoung ; Bae, Hee Joon. / The significance of blood pressure variability for the development of hemorrhagic transformation in acute ischemic stroke. In: Stroke. 2010 ; Vol. 41, No. 11. pp. 2512-2518.
@article{2c10173e389e4614960cc7ef35444762,
title = "The significance of blood pressure variability for the development of hemorrhagic transformation in acute ischemic stroke",
abstract = "Background and Purpose: Elevated blood pressure (BP) is commonly observed in acute ischemic stroke and is known to be associated with hemorrhagic transformation (HT). However, the effect of BP variability on the development of HT is not known well. Methods: A consecutive series of patients with acute ischemic stroke, who were hospitalized within 24 hours of onset and showed no HT on initial gradient echo MRI, were enrolled in this study. BP measurements during the first 72 hours were obtained, and BP variability of each patient was described using various summary parameters: SD, maximum (max), minimum (min), difference between max and min (max-min), average squared difference between successive measurements (sv), and maximum sv (svmax). Results: Of 792 patients meeting the eligibility criteria, 70 (8.8{\%}) developed HT. Among BP variability parameters categorized into quartiles, SBPmax, SBPmin, SBPmax-min, SBPsvmax, DBPSD, DBPmax, DBP min, DBPmax-min, and DBPsvmax were significantly associated with HT independent of mean SBP, age, interval from onset to arrival, initial stroke severity, diabetes mellitus, stroke subtype, thrombolysis, initial glucose, and total cholesterol (P<0.05 on likelihood ratio test of trend). The analyses about the interaction between thrombolysis and variability parameters showed that the effects of BP variability on the development of HT did not differ by whether patients received thrombolysis or not. Conclusions: Our study suggests that we may consider not only the absolute level of BP but also its variability to prevent hemorrhagic transformation.",
keywords = "blood pressure, cerebral infarction, hemorrhage",
author = "Youngchai Ko and Park, {Jung Hyun} and Yang, {Mi Hwa} and Ko, {Sang Bae} and Han, {Moon Ku} and Oh, {Chang Wan} and Jisung Lee and Juneyoung Lee and Bae, {Hee Joon}",
year = "2010",
month = "11",
day = "1",
doi = "10.1161/STROKEAHA.110.595561",
language = "English",
volume = "41",
pages = "2512--2518",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - The significance of blood pressure variability for the development of hemorrhagic transformation in acute ischemic stroke

AU - Ko, Youngchai

AU - Park, Jung Hyun

AU - Yang, Mi Hwa

AU - Ko, Sang Bae

AU - Han, Moon Ku

AU - Oh, Chang Wan

AU - Lee, Jisung

AU - Lee, Juneyoung

AU - Bae, Hee Joon

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Background and Purpose: Elevated blood pressure (BP) is commonly observed in acute ischemic stroke and is known to be associated with hemorrhagic transformation (HT). However, the effect of BP variability on the development of HT is not known well. Methods: A consecutive series of patients with acute ischemic stroke, who were hospitalized within 24 hours of onset and showed no HT on initial gradient echo MRI, were enrolled in this study. BP measurements during the first 72 hours were obtained, and BP variability of each patient was described using various summary parameters: SD, maximum (max), minimum (min), difference between max and min (max-min), average squared difference between successive measurements (sv), and maximum sv (svmax). Results: Of 792 patients meeting the eligibility criteria, 70 (8.8%) developed HT. Among BP variability parameters categorized into quartiles, SBPmax, SBPmin, SBPmax-min, SBPsvmax, DBPSD, DBPmax, DBP min, DBPmax-min, and DBPsvmax were significantly associated with HT independent of mean SBP, age, interval from onset to arrival, initial stroke severity, diabetes mellitus, stroke subtype, thrombolysis, initial glucose, and total cholesterol (P<0.05 on likelihood ratio test of trend). The analyses about the interaction between thrombolysis and variability parameters showed that the effects of BP variability on the development of HT did not differ by whether patients received thrombolysis or not. Conclusions: Our study suggests that we may consider not only the absolute level of BP but also its variability to prevent hemorrhagic transformation.

AB - Background and Purpose: Elevated blood pressure (BP) is commonly observed in acute ischemic stroke and is known to be associated with hemorrhagic transformation (HT). However, the effect of BP variability on the development of HT is not known well. Methods: A consecutive series of patients with acute ischemic stroke, who were hospitalized within 24 hours of onset and showed no HT on initial gradient echo MRI, were enrolled in this study. BP measurements during the first 72 hours were obtained, and BP variability of each patient was described using various summary parameters: SD, maximum (max), minimum (min), difference between max and min (max-min), average squared difference between successive measurements (sv), and maximum sv (svmax). Results: Of 792 patients meeting the eligibility criteria, 70 (8.8%) developed HT. Among BP variability parameters categorized into quartiles, SBPmax, SBPmin, SBPmax-min, SBPsvmax, DBPSD, DBPmax, DBP min, DBPmax-min, and DBPsvmax were significantly associated with HT independent of mean SBP, age, interval from onset to arrival, initial stroke severity, diabetes mellitus, stroke subtype, thrombolysis, initial glucose, and total cholesterol (P<0.05 on likelihood ratio test of trend). The analyses about the interaction between thrombolysis and variability parameters showed that the effects of BP variability on the development of HT did not differ by whether patients received thrombolysis or not. Conclusions: Our study suggests that we may consider not only the absolute level of BP but also its variability to prevent hemorrhagic transformation.

KW - blood pressure

KW - cerebral infarction

KW - hemorrhage

UR - http://www.scopus.com/inward/record.url?scp=78149300915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149300915&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.110.595561

DO - 10.1161/STROKEAHA.110.595561

M3 - Article

C2 - 20947842

AN - SCOPUS:78149300915

VL - 41

SP - 2512

EP - 2518

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 11

ER -