The significance of mismatch repair genes in gastric cancer

Hye Jeong Lee, You-Jin Jang, Eun Jung Lee, Jong Han Kim, Sungsoo Park, Seong-Heum Park, Chong Suk Kim, Young Jae Mok

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Microsatellite instability (MSI) is a form of genetic instability characterized by new alleles not present in the normal genotype. This mutation occurs by altered DNA mismatch repair (MMR) genes. Studies of limited numbers of patients have reported conflicting results regarding the association of the MSI phenotype with gastric cancer. This study aims to evaluate the clinical significance of mismatch repair genes in gastric cancer. Materials and Methods: We studied 156 gastric cancer patients who underwent gastrectomy from March 2010 to February 2011 in our hospital. Mismatch repair status was determined by the immunohistochemical analysis of human MutL Homolog 1 (hMLH1) and human MutS Homolog 2 (hMSH2) expression. Results: Seventeen (10.9%) cases did not express hMLH1 but all cases expressed hMSH2. In univariate analyses, the expression of hMLH1 was associated with age, nodal status, and Lauren's classification. In multivariate analyses, there was no statistically significant association between the loss of hMLH1 expression and selected clinical parameters. Conclusion: The expression of hMLH1 was associated with age, nodal status, and Lauren's classification. Our results suggest that MMR gene abnormalities play an important role in the tumorigenesis of patients demonstrating gastric cancer.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalJournal of Cancer Research and Therapeutics
Volume9
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

DNA Mismatch Repair
Stomach Neoplasms
Genes
Microsatellite Instability
Gastrectomy
Carcinogenesis
Multivariate Analysis
Alleles
Genotype
MutL Protein Homolog 1
Phenotype
Mutation

Keywords

  • Human MutL Homolog 1
  • human MutS Homolog 2
  • mismatch repair

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

The significance of mismatch repair genes in gastric cancer. / Lee, Hye Jeong; Jang, You-Jin; Lee, Eun Jung; Kim, Jong Han; Park, Sungsoo; Park, Seong-Heum; Kim, Chong Suk; Mok, Young Jae.

In: Journal of Cancer Research and Therapeutics, Vol. 9, No. 1, 01.01.2013, p. 80-83.

Research output: Contribution to journalArticle

@article{21bb094fd7f4483ebdb6488664406b1c,
title = "The significance of mismatch repair genes in gastric cancer",
abstract = "Background: Microsatellite instability (MSI) is a form of genetic instability characterized by new alleles not present in the normal genotype. This mutation occurs by altered DNA mismatch repair (MMR) genes. Studies of limited numbers of patients have reported conflicting results regarding the association of the MSI phenotype with gastric cancer. This study aims to evaluate the clinical significance of mismatch repair genes in gastric cancer. Materials and Methods: We studied 156 gastric cancer patients who underwent gastrectomy from March 2010 to February 2011 in our hospital. Mismatch repair status was determined by the immunohistochemical analysis of human MutL Homolog 1 (hMLH1) and human MutS Homolog 2 (hMSH2) expression. Results: Seventeen (10.9{\%}) cases did not express hMLH1 but all cases expressed hMSH2. In univariate analyses, the expression of hMLH1 was associated with age, nodal status, and Lauren's classification. In multivariate analyses, there was no statistically significant association between the loss of hMLH1 expression and selected clinical parameters. Conclusion: The expression of hMLH1 was associated with age, nodal status, and Lauren's classification. Our results suggest that MMR gene abnormalities play an important role in the tumorigenesis of patients demonstrating gastric cancer.",
keywords = "Human MutL Homolog 1, human MutS Homolog 2, mismatch repair",
author = "Lee, {Hye Jeong} and You-Jin Jang and Lee, {Eun Jung} and Kim, {Jong Han} and Sungsoo Park and Seong-Heum Park and Kim, {Chong Suk} and Mok, {Young Jae}",
year = "2013",
month = "1",
day = "1",
doi = "10.4103/0973-1482.110382",
language = "English",
volume = "9",
pages = "80--83",
journal = "Journal of Cancer Research and Therapeutics",
issn = "0973-1482",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

TY - JOUR

T1 - The significance of mismatch repair genes in gastric cancer

AU - Lee, Hye Jeong

AU - Jang, You-Jin

AU - Lee, Eun Jung

AU - Kim, Jong Han

AU - Park, Sungsoo

AU - Park, Seong-Heum

AU - Kim, Chong Suk

AU - Mok, Young Jae

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: Microsatellite instability (MSI) is a form of genetic instability characterized by new alleles not present in the normal genotype. This mutation occurs by altered DNA mismatch repair (MMR) genes. Studies of limited numbers of patients have reported conflicting results regarding the association of the MSI phenotype with gastric cancer. This study aims to evaluate the clinical significance of mismatch repair genes in gastric cancer. Materials and Methods: We studied 156 gastric cancer patients who underwent gastrectomy from March 2010 to February 2011 in our hospital. Mismatch repair status was determined by the immunohistochemical analysis of human MutL Homolog 1 (hMLH1) and human MutS Homolog 2 (hMSH2) expression. Results: Seventeen (10.9%) cases did not express hMLH1 but all cases expressed hMSH2. In univariate analyses, the expression of hMLH1 was associated with age, nodal status, and Lauren's classification. In multivariate analyses, there was no statistically significant association between the loss of hMLH1 expression and selected clinical parameters. Conclusion: The expression of hMLH1 was associated with age, nodal status, and Lauren's classification. Our results suggest that MMR gene abnormalities play an important role in the tumorigenesis of patients demonstrating gastric cancer.

AB - Background: Microsatellite instability (MSI) is a form of genetic instability characterized by new alleles not present in the normal genotype. This mutation occurs by altered DNA mismatch repair (MMR) genes. Studies of limited numbers of patients have reported conflicting results regarding the association of the MSI phenotype with gastric cancer. This study aims to evaluate the clinical significance of mismatch repair genes in gastric cancer. Materials and Methods: We studied 156 gastric cancer patients who underwent gastrectomy from March 2010 to February 2011 in our hospital. Mismatch repair status was determined by the immunohistochemical analysis of human MutL Homolog 1 (hMLH1) and human MutS Homolog 2 (hMSH2) expression. Results: Seventeen (10.9%) cases did not express hMLH1 but all cases expressed hMSH2. In univariate analyses, the expression of hMLH1 was associated with age, nodal status, and Lauren's classification. In multivariate analyses, there was no statistically significant association between the loss of hMLH1 expression and selected clinical parameters. Conclusion: The expression of hMLH1 was associated with age, nodal status, and Lauren's classification. Our results suggest that MMR gene abnormalities play an important role in the tumorigenesis of patients demonstrating gastric cancer.

KW - Human MutL Homolog 1

KW - human MutS Homolog 2

KW - mismatch repair

UR - http://www.scopus.com/inward/record.url?scp=84877285202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877285202&partnerID=8YFLogxK

U2 - 10.4103/0973-1482.110382

DO - 10.4103/0973-1482.110382

M3 - Article

C2 - 23575079

AN - SCOPUS:84877285202

VL - 9

SP - 80

EP - 83

JO - Journal of Cancer Research and Therapeutics

JF - Journal of Cancer Research and Therapeutics

SN - 0973-1482

IS - 1

ER -