The significances of lymph node micrometastasis and its correlation with E-cadherin expression in pT1-T3N0 gastric adenocarcinoma

Jong Han Kim, Joong Min Park, Cheol Woong Jung, Sungsoo Park, Seung Joo Kim, Young Jae Mok, Chong Suk Kim, Yang Seok Chae, Jeoung Won Bae

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: Recently, micrometastasis (MM) in the lymph node in gastric cancer has been detected by cytokeratin immunostaining. However, clinical significance of MM and its relationship with reduced expression of E-cadherin in primary lesion have not been well studied. Methods: The 4,990 lymph nodes from 184 pT1∼T3N0 patients from 1995 to 2000 at Korea University Hospital were immunostained with the anticytokeratin AE1/3 antibody for detection of micometastasis. The primary lesions were also immunostained for E-cadherin expression. Results: MM in the lymph node of gastric cancer was found in 131 (2.6%) of total dissected nodes, and 31 of 184 patients (16.8%) were shown to have MM. The MM was significantly correlated with the depth of invasion, tumor size, operation method, Lauren classification, lymphovascular invasion and loss of E-cadherin expression in primary tumor. On multivariate analysis, the independent risk factors for MM were the depth of invasion and loss of E-cadherin expression. The patients with MM had significantly lower 5-year overall and disease free survival rate than those without MM. Conclusion: Lymph node MM in histologically node-negative gastric cancer was significantly correlated with poor 5-year survival rate. The determination of E-cadherin expression in primary gastric tumor may be useful in prediction of the MM.

Original languageEnglish
Pages (from-to)125-130
Number of pages6
JournalJournal of Surgical Oncology
Volume97
Issue number2
DOIs
Publication statusPublished - 2008 Jan 1

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Neoplasm Micrometastasis
Cadherins
Stomach
Adenocarcinoma
Lymph Nodes
Stomach Neoplasms
Survival Rate
Neoplasms
Korea
Keratins
Disease-Free Survival
Multivariate Analysis

Keywords

  • E-cadherin
  • Gastric cancer
  • Lymph node micrometastasis

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

The significances of lymph node micrometastasis and its correlation with E-cadherin expression in pT1-T3N0 gastric adenocarcinoma. / Kim, Jong Han; Park, Joong Min; Jung, Cheol Woong; Park, Sungsoo; Kim, Seung Joo; Mok, Young Jae; Kim, Chong Suk; Chae, Yang Seok; Bae, Jeoung Won.

In: Journal of Surgical Oncology, Vol. 97, No. 2, 01.01.2008, p. 125-130.

Research output: Contribution to journalArticle

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abstract = "Background: Recently, micrometastasis (MM) in the lymph node in gastric cancer has been detected by cytokeratin immunostaining. However, clinical significance of MM and its relationship with reduced expression of E-cadherin in primary lesion have not been well studied. Methods: The 4,990 lymph nodes from 184 pT1∼T3N0 patients from 1995 to 2000 at Korea University Hospital were immunostained with the anticytokeratin AE1/3 antibody for detection of micometastasis. The primary lesions were also immunostained for E-cadherin expression. Results: MM in the lymph node of gastric cancer was found in 131 (2.6{\%}) of total dissected nodes, and 31 of 184 patients (16.8{\%}) were shown to have MM. The MM was significantly correlated with the depth of invasion, tumor size, operation method, Lauren classification, lymphovascular invasion and loss of E-cadherin expression in primary tumor. On multivariate analysis, the independent risk factors for MM were the depth of invasion and loss of E-cadherin expression. The patients with MM had significantly lower 5-year overall and disease free survival rate than those without MM. Conclusion: Lymph node MM in histologically node-negative gastric cancer was significantly correlated with poor 5-year survival rate. The determination of E-cadherin expression in primary gastric tumor may be useful in prediction of the MM.",
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AU - Kim, Seung Joo

AU - Mok, Young Jae

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AU - Chae, Yang Seok

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AB - Background: Recently, micrometastasis (MM) in the lymph node in gastric cancer has been detected by cytokeratin immunostaining. However, clinical significance of MM and its relationship with reduced expression of E-cadherin in primary lesion have not been well studied. Methods: The 4,990 lymph nodes from 184 pT1∼T3N0 patients from 1995 to 2000 at Korea University Hospital were immunostained with the anticytokeratin AE1/3 antibody for detection of micometastasis. The primary lesions were also immunostained for E-cadherin expression. Results: MM in the lymph node of gastric cancer was found in 131 (2.6%) of total dissected nodes, and 31 of 184 patients (16.8%) were shown to have MM. The MM was significantly correlated with the depth of invasion, tumor size, operation method, Lauren classification, lymphovascular invasion and loss of E-cadherin expression in primary tumor. On multivariate analysis, the independent risk factors for MM were the depth of invasion and loss of E-cadherin expression. The patients with MM had significantly lower 5-year overall and disease free survival rate than those without MM. Conclusion: Lymph node MM in histologically node-negative gastric cancer was significantly correlated with poor 5-year survival rate. The determination of E-cadherin expression in primary gastric tumor may be useful in prediction of the MM.

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