The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer

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Abstract

Background/Aims: Chemotherapy combined with radiation therapy is the standard treatment for limited stage small cell lung cancer (LS-SCLC). Although numerous studies indicate that the overall duration of chemoradiotherapy is the most relevant predictor of outcome, the optimal chemotherapy and radiation schedule for LS-SCLC remains controversial. Therefore we analyzed the time from the start of any treatment until the end of radiotherapy (SER) in patients with LS-SCLC. Methods: We retrospectively analyzed 29 patients diagnosed histologically with LS-SCLC and divided them into two groups: a short SER group (< 60 days) and a long SER (> 60 days) group. Patients were treated with irinotecan-based chemotherapy and thoracic radiotherapy. Results: Sixteen patients were in the short SER group and 13 patients were in the long SER group. Short SER significantly prolonged survival rate (p = 0.03) compared with that of long SER. However, no significant differences in side effects were observed. Conclusions: Short SER should be considered to improve the outcome of concurrent chemoradiotherapy for LS-SCLC.

Original languageEnglish
Pages (from-to)449-455
Number of pages7
JournalKorean Journal of Internal Medicine
Volume28
Issue number4
DOIs
Publication statusPublished - 2013 Jul 1

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Keywords

  • Chemoradiotherapy
  • Limited-stage
  • Small cell lung carcinoma
  • Start of any treatment until the end of radiotherapy

ASJC Scopus subject areas

  • Internal Medicine

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