The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer

Kyoung Ju Lee, Eun Joo Lee, Gyu Young Hur, Sang Yeub Lee, Je Hyeong Kim, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo, Sung Yong Lee

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3 Citations (Scopus)

Abstract

Background/Aims: Chemotherapy combined with radiation therapy is the standard treatment for limited stage small cell lung cancer (LS-SCLC). Although numerous studies indicate that the overall duration of chemoradiotherapy is the most relevant predictor of outcome, the optimal chemotherapy and radiation schedule for LS-SCLC remains controversial. Therefore we analyzed the time from the start of any treatment until the end of radiotherapy (SER) in patients with LS-SCLC. Methods: We retrospectively analyzed 29 patients diagnosed histologically with LS-SCLC and divided them into two groups: a short SER group (< 60 days) and a long SER (> 60 days) group. Patients were treated with irinotecan-based chemotherapy and thoracic radiotherapy. Results: Sixteen patients were in the short SER group and 13 patients were in the long SER group. Short SER significantly prolonged survival rate (p = 0.03) compared with that of long SER. However, no significant differences in side effects were observed. Conclusions: Short SER should be considered to improve the outcome of concurrent chemoradiotherapy for LS-SCLC.

Original languageEnglish
Pages (from-to)449-455
Number of pages7
JournalKorean Journal of Internal Medicine
Volume28
Issue number4
DOIs
Publication statusPublished - 2013 Jul

Keywords

  • Chemoradiotherapy
  • Limited-stage
  • Small cell lung carcinoma
  • Start of any treatment until the end of radiotherapy

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Lee, K. J., Lee, E. J., Hur, G. Y., Lee, S. Y., Kim, J. H., Shin, C., Shim, J. J., In, K. H., Kang, K. H., Yoo, S. H., & Lee, S. Y. (2013). The start of chemotherapy until the end of radiotherapy in patients with limited-stage small cell lung cancer. Korean Journal of Internal Medicine, 28(4), 449-455. https://doi.org/10.3904/kjim.2013.28.4.449