The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

Yong Park, Dae Sik Kim, Seh Jong Park, Hee Yun Seo, Se Ryeon Lee, Hwa Jung Sung, Kyong Hwa Park, In Keun Choi, Seok Jin Kim, Sang Cheul Oh, Jae Hong Seo, Chul Won Choi, Byung Soo Kim, Sang Won Shin, Yeul Hong Kim, Jun Suk Kim

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.

Original languageEnglish
Pages (from-to)294-300
Number of pages7
JournalLeukemia Research
Volume34
Issue number3
DOIs
Publication statusPublished - 2010 Mar

Keywords

  • Albumin
  • Bicarbonate
  • C-reactive protein
  • Febrile neutropenia
  • Hematologic malignancy
  • Prognosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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