The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

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12 Citations (Scopus)

Abstract

We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.

Original languageEnglish
Pages (from-to)294-300
Number of pages7
JournalLeukemia Research
Volume34
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

Fingerprint

Febrile Neutropenia
Hematologic Diseases
Bicarbonates
Serum Albumin
Neutropenia
Respiratory Tract Infections
Multivariate Analysis
Prospective Studies
Anti-Bacterial Agents
Drug Therapy
Therapeutics

Keywords

  • Albumin
  • Bicarbonate
  • C-reactive protein
  • Febrile neutropenia
  • Hematologic malignancy
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

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title = "The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease",
abstract = "We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.",
keywords = "Albumin, Bicarbonate, C-reactive protein, Febrile neutropenia, Hematologic malignancy, Prognosis",
author = "Yong Park and Kim, {Dae Sik} and Park, {Seh Jong} and Seo, {Hee Yun} and Lee, {Se Ryeon} and Sung, {Hwa Jung} and Park, {Kyong Hwa} and Choi, {In Keun} and Kim, {Seok Jin} and Oh, {Sang Cheul} and Seo, {Jae Hong} and Choi, {Chul Won} and Kim, {Byung Soo} and Shin, {Sang Won} and Kim, {Yeul Hong} and Kim, {Jun Suk}",
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T1 - The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

AU - Park, Yong

AU - Kim, Dae Sik

AU - Park, Seh Jong

AU - Seo, Hee Yun

AU - Lee, Se Ryeon

AU - Sung, Hwa Jung

AU - Park, Kyong Hwa

AU - Choi, In Keun

AU - Kim, Seok Jin

AU - Oh, Sang Cheul

AU - Seo, Jae Hong

AU - Choi, Chul Won

AU - Kim, Byung Soo

AU - Shin, Sang Won

AU - Kim, Yeul Hong

AU - Kim, Jun Suk

PY - 2010/3/1

Y1 - 2010/3/1

N2 - We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.

AB - We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.

KW - Albumin

KW - Bicarbonate

KW - C-reactive protein

KW - Febrile neutropenia

KW - Hematologic malignancy

KW - Prognosis

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JO - Leukemia Research

JF - Leukemia Research

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