The survival outcome and prognostic factors for middle and distal bile duct cancer following surgical resection

Sae-Byeol Choi, Woo Park Seung, Sik Kim Kyung, Sub Choi Jin, Jung Lee Woo

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background and Objectives: The objective of this study was to analyze the survival outcome and the clinicopathological factors that influence survival and recurrence of middle and distal bile duct cancer after surgical resection. Methods: From January 2000 to June 2007, 125 patients underwent surgical resection for middle and distal bile duct cancer. The clinicopathological characteristics and survival outcomes were reviewed retrospectively. Results: Of the 125 patients, 31 patients underwent segmental resection of the bile duct, and 94 patients underwent pancreaticoduodenectomy (PD). Overall survival rates were 85.8% at 1 year and 38.3% at 5 years. Lymph node metastasis, noncurative resection, poorly differentiated tumor, and preoperative bilirubin level greater than 5.0 mg/dl were significant independent predictors of poor prognosis by multivariate analysis. The number of metastatic lymph nodes did not significantly affect survival. Recurrence occurred in 72 patients (61.0%). Disease-free survival rates were 74.1% at 1 year and 42.0% at 3 years. Lymph node and distant metastases and poorly differentiated tumors were found to be significant independent predictors of recurrence by multivariate analysis. Conclusions: R0 resection confers a survival benefit, thus the surgeon should make an effort to achieve R0 resection. The presence of lymph node metastasis was a significant prognostic factor.

Original languageEnglish
Pages (from-to)335-342
Number of pages8
JournalJournal of Surgical Oncology
Volume99
Issue number6
DOIs
Publication statusPublished - 2009 May 1
Externally publishedYes

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Bile Duct Neoplasms
Lymph Nodes
Survival
Neoplasm Metastasis
Recurrence
Multivariate Analysis
Survival Rate
Pancreaticoduodenectomy
Survival Analysis
Bile Ducts
Bilirubin
Disease-Free Survival
Neoplasms

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

The survival outcome and prognostic factors for middle and distal bile duct cancer following surgical resection. / Choi, Sae-Byeol; Seung, Woo Park; Kyung, Sik Kim; Jin, Sub Choi; Woo, Jung Lee.

In: Journal of Surgical Oncology, Vol. 99, No. 6, 01.05.2009, p. 335-342.

Research output: Contribution to journalArticle

Choi, Sae-Byeol ; Seung, Woo Park ; Kyung, Sik Kim ; Jin, Sub Choi ; Woo, Jung Lee. / The survival outcome and prognostic factors for middle and distal bile duct cancer following surgical resection. In: Journal of Surgical Oncology. 2009 ; Vol. 99, No. 6. pp. 335-342.
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