The synchronization within and interaction between the default and dorsal attention networks in early infancy

Wei Gao, John H. Gilmore, Dinggang Shen, Jeffery Keith Smith, Hongtu Zhu, Weili Lin

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

An anticorrelated interaction between the dorsal attention and the default-mode networks has been observed, although how these 2 networks establish such relationship remains elusive. Behavioral studies have reported the emergence of attention and default network-related functions and a preliminary competing relationship between them at early infancy. This study attempted to test the hypothesis - resting-state functional magnetic resonance imaging will demonstrate not only improved network synchronization of the dorsal attention and the default networks, respectively, during the first 2 years of life but also an anticorrelated network interaction pattern between the 2 networks at 1 year which will be further enhanced at 2 years old. Our results demonstrate that both networks start from an isolated region in neonates but evolve to highly synchronized networks at 1 year old. Paralleling the individual network maturation process, the anticorrelated behaviors are absent at birth but become apparent at 1 year and are further enhanced during the second year of life. Our studies elucidate not only the individual maturation process of the dorsal attention and default networks but also offer evidence that the maturation of the individual networks may be needed prior exhibiting the adult-like interaction patterns between the 2 networks.

Original languageEnglish
Pages (from-to)594-603
Number of pages10
JournalCerebral Cortex
Volume23
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • anticorrelation
  • brain development
  • fMRI
  • functional connectivity
  • resting state

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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