The T allele of the interferon-gamma +874A/T polymorphism is associated with bipolar disorder

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Abstract

Background: Previous studies have shown that patients with bipolar disorder (BD) tend to have altered immune system function. Several studies have reported that changes in interferon-gamma (IFN-γ) may play an important role in the development of BD. Aims: To investigate the relationship between IFN-γ and BD, 156 patients with BD and 175 control subjects were genotyped for the IFN-γ +874A/T single nucleotide polymorphism. Results: We detected significant differences in the genotype distributions and allele frequencies of the IFN-γ +874A/T single nucleotide polymorphism (rs2430561) between patients with BD and normal controls. The T allele was found to be significantly more common among patients with BD than in controls. Additionally, significant differences in scores on the Young Mania Rating Scale (YMRS) were found between the three genotypes of this polymorphism. Conclusions: Our results suggest that the IFN-γ +874A/T polymorphism may have important effects related to susceptibility to BD and that the T allele may be associated with an increased risk of developing BD.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalNordic Journal of Psychiatry
Volume66
Issue number1
DOIs
Publication statusPublished - 2012 Feb 1

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Bipolar Disorder
Interferon-gamma
Alleles
Single Nucleotide Polymorphism
Genotype
Gene Frequency
Immune System

Keywords

  • Bipolar disorder
  • Interferon-gamma
  • Polymorphism

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

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title = "The T allele of the interferon-gamma +874A/T polymorphism is associated with bipolar disorder",
abstract = "Background: Previous studies have shown that patients with bipolar disorder (BD) tend to have altered immune system function. Several studies have reported that changes in interferon-gamma (IFN-γ) may play an important role in the development of BD. Aims: To investigate the relationship between IFN-γ and BD, 156 patients with BD and 175 control subjects were genotyped for the IFN-γ +874A/T single nucleotide polymorphism. Results: We detected significant differences in the genotype distributions and allele frequencies of the IFN-γ +874A/T single nucleotide polymorphism (rs2430561) between patients with BD and normal controls. The T allele was found to be significantly more common among patients with BD than in controls. Additionally, significant differences in scores on the Young Mania Rating Scale (YMRS) were found between the three genotypes of this polymorphism. Conclusions: Our results suggest that the IFN-γ +874A/T polymorphism may have important effects related to susceptibility to BD and that the T allele may be associated with an increased risk of developing BD.",
keywords = "Bipolar disorder, Interferon-gamma, Polymorphism",
author = "Ho-Kyoung Yoon and Kim, {Yong Ku}",
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T1 - The T allele of the interferon-gamma +874A/T polymorphism is associated with bipolar disorder

AU - Yoon, Ho-Kyoung

AU - Kim, Yong Ku

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N2 - Background: Previous studies have shown that patients with bipolar disorder (BD) tend to have altered immune system function. Several studies have reported that changes in interferon-gamma (IFN-γ) may play an important role in the development of BD. Aims: To investigate the relationship between IFN-γ and BD, 156 patients with BD and 175 control subjects were genotyped for the IFN-γ +874A/T single nucleotide polymorphism. Results: We detected significant differences in the genotype distributions and allele frequencies of the IFN-γ +874A/T single nucleotide polymorphism (rs2430561) between patients with BD and normal controls. The T allele was found to be significantly more common among patients with BD than in controls. Additionally, significant differences in scores on the Young Mania Rating Scale (YMRS) were found between the three genotypes of this polymorphism. Conclusions: Our results suggest that the IFN-γ +874A/T polymorphism may have important effects related to susceptibility to BD and that the T allele may be associated with an increased risk of developing BD.

AB - Background: Previous studies have shown that patients with bipolar disorder (BD) tend to have altered immune system function. Several studies have reported that changes in interferon-gamma (IFN-γ) may play an important role in the development of BD. Aims: To investigate the relationship between IFN-γ and BD, 156 patients with BD and 175 control subjects were genotyped for the IFN-γ +874A/T single nucleotide polymorphism. Results: We detected significant differences in the genotype distributions and allele frequencies of the IFN-γ +874A/T single nucleotide polymorphism (rs2430561) between patients with BD and normal controls. The T allele was found to be significantly more common among patients with BD than in controls. Additionally, significant differences in scores on the Young Mania Rating Scale (YMRS) were found between the three genotypes of this polymorphism. Conclusions: Our results suggest that the IFN-γ +874A/T polymorphism may have important effects related to susceptibility to BD and that the T allele may be associated with an increased risk of developing BD.

KW - Bipolar disorder

KW - Interferon-gamma

KW - Polymorphism

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