The timing of external input controls the sign of plasticity at local synapses

Jeehyun Kwag; Ole Paulsen

doi:10.1038/nn.2388

The timing of external input controls the sign of plasticity at local synapses

Jeehyun Kwag, Ole Paulsen

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

Original language	English
Pages (from-to)	1219-1221
Number of pages	3
Journal	Nature Neuroscience
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/nn.2388
Publication status	Published - 2009 Oct
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn.2388

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title = "The timing of external input controls the sign of plasticity at local synapses",

abstract = "The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.",

author = "Jeehyun Kwag and Ole Paulsen",

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AB - The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

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The timing of external input controls the sign of plasticity at local synapses

Abstract

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