The timing of external input controls the sign of plasticity at local synapses

Jeehyun Kwag, Ole Paulsen

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

Original languageEnglish
Pages (from-to)1219-1221
Number of pages3
JournalNature Neuroscience
Volume12
Issue number10
DOIs
Publication statusPublished - 2009 Oct 1
Externally publishedYes

Fingerprint

Synapses
Hippocampus
Weights and Measures
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The timing of external input controls the sign of plasticity at local synapses. / Kwag, Jeehyun; Paulsen, Ole.

In: Nature Neuroscience, Vol. 12, No. 10, 01.10.2009, p. 1219-1221.

Research output: Contribution to journalArticle

@article{e400fdd1623a45648341727fc6170117,
title = "The timing of external input controls the sign of plasticity at local synapses",
abstract = "The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.",
author = "Jeehyun Kwag and Ole Paulsen",
year = "2009",
month = "10",
day = "1",
doi = "10.1038/nn.2388",
language = "English",
volume = "12",
pages = "1219--1221",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - The timing of external input controls the sign of plasticity at local synapses

AU - Kwag, Jeehyun

AU - Paulsen, Ole

PY - 2009/10/1

Y1 - 2009/10/1

N2 - The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

AB - The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

UR - http://www.scopus.com/inward/record.url?scp=70349554206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349554206&partnerID=8YFLogxK

U2 - 10.1038/nn.2388

DO - 10.1038/nn.2388

M3 - Article

C2 - 19734896

AN - SCOPUS:70349554206

VL - 12

SP - 1219

EP - 1221

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 10

ER -