The timing of external input controls the sign of plasticity at local synapses

Jeehyun Kwag, Ole Paulsen

Research output: Contribution to journalArticle

37 Citations (Scopus)


The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

Original languageEnglish
Pages (from-to)1219-1221
Number of pages3
JournalNature Neuroscience
Issue number10
Publication statusPublished - 2009 Oct 1
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

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