The treatment of diabetic foot ulcers with uncultured, processed lipoaspirate cells

A pilot study

Seung-Kyu Han, Hong Ryul Kim, Woo-Kyung Kim

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Human processed lipoaspirate (PLA) cells are relatively easy to obtain in large quantities without cell culture. The purpose of this study was to present the possibility of using uncultured PLA cell autografts for the treatment of diabetic ulcers. An in vitro study was designed initially to determine the effect of PLA cell autografts on the proliferation and collagen synthesis of diabetic fibroblasts (n54). In a subsequent clinical study, 26 patients with diabetic foot ulcers were treated using PLA cell autografts. Control treatment was also performed in 26 patients. Eight weeks after treatment, the percentages of complete healing and mean healing times were compared. Cell proliferation and collagen synthesis in the PLA cell treatment group were 28 and 44% higher than that in the control group in vitro, respectively. Our clinical study showed that 100% of the PLA celltreated group and 62% of the control group achieved complete healing. The PLA cell treatment was also superior to the conventional method in terms of the healing time. No adverse events related to the study treatment occurred. Uncultured PLA cell autografts stimulate the activity of diabetic fibroblasts and may offer a simple and effective treatment for diabetic ulcers.

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalWound Repair and Regeneration
Volume18
Issue number4
DOIs
Publication statusPublished - 2010 Jul 1

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Diabetic Foot
Autografts
Therapeutics
Ulcer
Collagen
Fibroblasts
Control Groups
Cell Culture Techniques
Cell Proliferation

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

The treatment of diabetic foot ulcers with uncultured, processed lipoaspirate cells : A pilot study. / Han, Seung-Kyu; Kim, Hong Ryul; Kim, Woo-Kyung.

In: Wound Repair and Regeneration, Vol. 18, No. 4, 01.07.2010, p. 342-348.

Research output: Contribution to journalArticle

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