The type III calcium/calmodulin-sensitive adenylyl cyclase is not specific to olfactory sensory neurons

Zhengui Xia, Eui Ju Choi, Fan Wang, Daniel R. Storm

Research output: Contribution to journalArticle

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Abstract

A cDNA clone for type III adenylyl cyclase was originally isolated from a rat olfactory cDNA library and Northern analysis using total RNA suggested that the expression of the type III mRNA may be limited to the olfactory epithelium (Bakalyar and Reed, Science, 250 (1990) 1403-1406). In this study, the distribution of type III adenylyl cyclase mRNA in a number of bovine tissues and cultured cells was examined by Northern analysis using poly(A)+ RNA. Type III adenylyl cyclase mRNA was expressed in brain, spinal cord, adrenal medulla, adrenal cortex, heart atrium, aorta, lung, retina, 293 cells and PC-12 cells. Furthermore, the Ca2+ sensitivity of adenylyl cyclase activity in 293 cells indicated the presence of type III adenylyl cyclase. These data indicate that expression of the type III adenylyl cyclase is not limited to olfactory tissues, and that this enzyme probably has a number of physiological functions in addition to olfactory signal transduction.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalNeuroscience Letters
Volume144
Issue number1-2
Publication statusPublished - 1992 Sep 14
Externally publishedYes

Fingerprint

Olfactory Receptor Neurons
Calmodulin
Adenylyl Cyclases
Calcium
Messenger RNA
Olfactory Mucosa
Adrenal Medulla
Adrenal Cortex
Heart Atria
Gene Library
Aorta
Retina
Cultured Cells
Signal Transduction
Spinal Cord
Complementary DNA
Clone Cells
adenylate cyclase 3
RNA
Lung

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The type III calcium/calmodulin-sensitive adenylyl cyclase is not specific to olfactory sensory neurons. / Xia, Zhengui; Choi, Eui Ju; Wang, Fan; Storm, Daniel R.

In: Neuroscience Letters, Vol. 144, No. 1-2, 14.09.1992, p. 169-173.

Research output: Contribution to journalArticle

Xia, Zhengui ; Choi, Eui Ju ; Wang, Fan ; Storm, Daniel R. / The type III calcium/calmodulin-sensitive adenylyl cyclase is not specific to olfactory sensory neurons. In: Neuroscience Letters. 1992 ; Vol. 144, No. 1-2. pp. 169-173.
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