The utility of bispectral index monitoring for prevention of rocuronium-induced withdrawal movement in children: A randomized controlled trial

Byung Gun Lim, Il Ok Lee, Young Sung Kim, Young Ju Won, Heezoo Kim, Myoung Hoon Kong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: This study was designed to determine whether a deep hypnotic state with a bispectral index (BIS) value less than 40 could alleviate withdrawal movement (WM) upon rocuronium injection during anesthesia induction in children. Methods: Finally, 135 healthy children (3-12 years) scheduled for minor elective surgery were studied. Without premedication, anesthesia was induced with thiopental sodium 5mg/kg. Patients were randomized into 2 groups (control vs experimental) and then by virtue of rocuronium injection time, patients in the experimental group were allocated into 2 groups, as follows: in the control group (group C; n=45), rocuronium 0.6mg/kg was administered at the loss of eyelash reflex; in the 1st experimental group, rocuronium 0.6 mg/kg was administered when BIS fell to less than 40 (group T; n=45); however, if BIS did not fall below 40 after thiopental sodium administration, manual ventilation was provided with oxygen 6L/minute using sevoflurane 8% and then rocuronium was administered when BIS fell below 40 (the 2nd experimental group, group S; n=45). Rocuronium-inducedWMwas evaluated using a 4-point scale (no movement; movement/withdrawal involving the arm only; generalized response, with movement/withdrawal of more than 1 extremity, but no requirement for restraint of the body; and generalized response which required restraint of the body and caused coughing or breath-holding). Results: No significant differences were found among the groups for patient characteristics including age, sex, height, and location of venous cannula. However, body weight, height, and body mass index in group S were all smaller than those in group T. The incidence of WM caused by rocuronium was 100% in group C, 95.6% in group T, and 80% in group S, and was significantly lower in group S than in group C. The grade ofWMwas 3.7±0.6 in group C, 3.2±0.9 in group T, and 2.6±1.0 in group S. It was significantly lower in group T than in group C and significantly lower in group S than in groups C and T. Conclusion: The confirmation of a deep hypnotic state with BIS values lower than 40 using BIS monitoring can reduce the grade of rocuronium-induced WMs during anesthesia induction using thiopental sodium or sevoflurane in children.

Original languageEnglish
Article numbere5871
JournalMedicine (United States)
Volume96
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • Anesthesia
  • Anesthesia
  • Anesthetics
  • Bispectral index monitor
  • Children
  • General
  • Inhalation
  • Rocuronium
  • Sevoflurane
  • Thiopental

ASJC Scopus subject areas

  • Medicine(all)

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