The utility of the human papillomavirus DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia

Kyeong A. So, Jin-Hwa Hong, Jong Ha Hwang, Seung Hun Song, Jae Kwan Lee, Nak Woo Lee, Kyu Wan Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objecti ve: We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). Methods: A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology and HPV DNA test, and colposcopic biopsies were taken at 3-to 6-month intervals. Thirty-seven patients were followed for more than 6 months; their HPV DNA test results were compared to the cytology results for the prediction of disease prognosis. Results: The degree of VAIN was more severe in patients with a high initial HPV DNA load (p=0.009). Patients with VAIN 2 and VAIN 3 were older than those with VAIN 1 (p=0.005 and 0.008, respectively). In 26 out of 37 patients (70.3%), the VAIN resolved. The other patients had persistent lesions with no progression to invasive vaginal carcinoma. The last follow-up HPV DNA load was significantly higher in the group with persistent VAIN compared to the group with resolved VAIN (p<0.0001). Negative cytology was observed in 25 out of 26 patients in the VAIN resolved group and in nine out of 11 patients in the VAIN persistent group (p=0.205). Conclusion: These results suggest that the HPV DNA test, especially for viral load, was more effective for the diagnosis and prediction of persistent VAIN than cytology.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalJournal of Gynecologic Oncology
Volume20
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1

    Fingerprint

Keywords

  • Human papillomavirus
  • Vaginal intraepithelial neoplasia
  • Viral load

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this