The within-host population dynamics of normal flora in the presence of an invading pathogen and antibiotic treatments

Jungmo Kim, Dong Hwan Lee, Yoon Seok Song, Seong Woo Kang, Seung Wook Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A mathematical competition model between normal flora and an invading pathogen was devised to allow analysis of bacterial infections in a host. The normal flora includes the various microorganisms that live on or within the host and act as a primary human immune system. Despite the important role of the normal flora, no mathematical study has been undertaken on models of the interaction between it and invading pathogens against a background of antibiotic treatment. To quantify key elements of bacterial behavior in a host, pairs of nonlinear differential equations were used to describe three categories of human health conditions, namely, healthy, latent infection, and active infection. In addition, a cutoff value was proposed to represent the minimum population level required for survival. The recovery of normal flora after antibiotic treatment was also included in the simulation because of its relation to human health recovery. The significance of each simulation parameter for the bacterial growth model was investigated. The devised simulation showed that bacterial proliferation rate, carrying capacity, initial population levels, and competition intensity have a significant effect on bacterial behavior. Consequently, a model was established to describe competition between normal flora and an infiltrating pathogen. Unlike other population models, the recovery process described by the devised model can describe the human health recovery mechanism.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalJournal of Microbiology and Biotechnology
Volume17
Issue number1
Publication statusPublished - 2007 Jan 1

Fingerprint

Population dynamics
Population Dynamics
Pathogens
Antibiotics
Anti-Bacterial Agents
Recovery
Health
Population
Conservation of Natural Resources
Infection
Bacterial Infections
Immune System
Theoretical Models
Immune system
Microorganisms
Survival
Differential equations
Growth

Keywords

  • Antibiotic treatments
  • Cutoff value
  • Normal flora
  • Population dynamics
  • Recovery process

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

Cite this

The within-host population dynamics of normal flora in the presence of an invading pathogen and antibiotic treatments. / Kim, Jungmo; Lee, Dong Hwan; Song, Yoon Seok; Kang, Seong Woo; Kim, Seung Wook.

In: Journal of Microbiology and Biotechnology, Vol. 17, No. 1, 01.01.2007, p. 146-153.

Research output: Contribution to journalArticle

@article{b1848eadc0344114aa70a0b34b9d89e6,
title = "The within-host population dynamics of normal flora in the presence of an invading pathogen and antibiotic treatments",
abstract = "A mathematical competition model between normal flora and an invading pathogen was devised to allow analysis of bacterial infections in a host. The normal flora includes the various microorganisms that live on or within the host and act as a primary human immune system. Despite the important role of the normal flora, no mathematical study has been undertaken on models of the interaction between it and invading pathogens against a background of antibiotic treatment. To quantify key elements of bacterial behavior in a host, pairs of nonlinear differential equations were used to describe three categories of human health conditions, namely, healthy, latent infection, and active infection. In addition, a cutoff value was proposed to represent the minimum population level required for survival. The recovery of normal flora after antibiotic treatment was also included in the simulation because of its relation to human health recovery. The significance of each simulation parameter for the bacterial growth model was investigated. The devised simulation showed that bacterial proliferation rate, carrying capacity, initial population levels, and competition intensity have a significant effect on bacterial behavior. Consequently, a model was established to describe competition between normal flora and an infiltrating pathogen. Unlike other population models, the recovery process described by the devised model can describe the human health recovery mechanism.",
keywords = "Antibiotic treatments, Cutoff value, Normal flora, Population dynamics, Recovery process",
author = "Jungmo Kim and Lee, {Dong Hwan} and Song, {Yoon Seok} and Kang, {Seong Woo} and Kim, {Seung Wook}",
year = "2007",
month = "1",
day = "1",
language = "English",
volume = "17",
pages = "146--153",
journal = "Journal of Microbiology and Biotechnology",
issn = "1017-7825",
publisher = "Korean Society for Microbiolog and Biotechnology",
number = "1",

}

TY - JOUR

T1 - The within-host population dynamics of normal flora in the presence of an invading pathogen and antibiotic treatments

AU - Kim, Jungmo

AU - Lee, Dong Hwan

AU - Song, Yoon Seok

AU - Kang, Seong Woo

AU - Kim, Seung Wook

PY - 2007/1/1

Y1 - 2007/1/1

N2 - A mathematical competition model between normal flora and an invading pathogen was devised to allow analysis of bacterial infections in a host. The normal flora includes the various microorganisms that live on or within the host and act as a primary human immune system. Despite the important role of the normal flora, no mathematical study has been undertaken on models of the interaction between it and invading pathogens against a background of antibiotic treatment. To quantify key elements of bacterial behavior in a host, pairs of nonlinear differential equations were used to describe three categories of human health conditions, namely, healthy, latent infection, and active infection. In addition, a cutoff value was proposed to represent the minimum population level required for survival. The recovery of normal flora after antibiotic treatment was also included in the simulation because of its relation to human health recovery. The significance of each simulation parameter for the bacterial growth model was investigated. The devised simulation showed that bacterial proliferation rate, carrying capacity, initial population levels, and competition intensity have a significant effect on bacterial behavior. Consequently, a model was established to describe competition between normal flora and an infiltrating pathogen. Unlike other population models, the recovery process described by the devised model can describe the human health recovery mechanism.

AB - A mathematical competition model between normal flora and an invading pathogen was devised to allow analysis of bacterial infections in a host. The normal flora includes the various microorganisms that live on or within the host and act as a primary human immune system. Despite the important role of the normal flora, no mathematical study has been undertaken on models of the interaction between it and invading pathogens against a background of antibiotic treatment. To quantify key elements of bacterial behavior in a host, pairs of nonlinear differential equations were used to describe three categories of human health conditions, namely, healthy, latent infection, and active infection. In addition, a cutoff value was proposed to represent the minimum population level required for survival. The recovery of normal flora after antibiotic treatment was also included in the simulation because of its relation to human health recovery. The significance of each simulation parameter for the bacterial growth model was investigated. The devised simulation showed that bacterial proliferation rate, carrying capacity, initial population levels, and competition intensity have a significant effect on bacterial behavior. Consequently, a model was established to describe competition between normal flora and an infiltrating pathogen. Unlike other population models, the recovery process described by the devised model can describe the human health recovery mechanism.

KW - Antibiotic treatments

KW - Cutoff value

KW - Normal flora

KW - Population dynamics

KW - Recovery process

UR - http://www.scopus.com/inward/record.url?scp=33846886912&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846886912&partnerID=8YFLogxK

M3 - Article

C2 - 18051366

AN - SCOPUS:33846886912

VL - 17

SP - 146

EP - 153

JO - Journal of Microbiology and Biotechnology

JF - Journal of Microbiology and Biotechnology

SN - 1017-7825

IS - 1

ER -