Theranostic nanomaterials for image-guided gene therapy

Seung Rim Hwang, Sook Hee Ku, Min Kyung Joo, Sun Hwa Kim, Ick Chan Kwon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Theranostics was proposed as a combined process of therapeutics and diagnostics methodology for increasing treatment efficacy and safety with simultaneous monitoring of the response to treatment. In the past two decades, nanotechnology has been the focus of developing strategies for drug delivery and imaging functions, and it has expanded to the design of multifunctional nanoparticles and the creation of nanotheranostics (i.e., theranostic nanomedicines). Nanotheranostics also shows potential in gene therapy; however, nanoparticle-mediated delivery of genes still faces major obstacles related to (1) the uptake by the reticuloendothelial system, (2) the ability to get across the target cell membranes through endocytosis, and (3) the ability to accumulate in organs with permeable vasculature. Here, we review the development and application of nanotheranostics, highlighting their relevance to gene therapy as well as molecular imaging.

Original languageEnglish
Pages (from-to)44-50
Number of pages7
JournalMRS Bulletin
Volume39
Issue number1
DOIs
Publication statusPublished - 2014 Jan 27
Externally publishedYes

Fingerprint

gene therapy
Gene therapy
Nanostructured materials
delivery
Nanoparticles
Medical nanotechnology
Molecular imaging
nanoparticles
Cell membranes
nanotechnology
Drug delivery
Nanotechnology
organs
genes
safety
drugs
Genes
methodology
Imaging techniques
Monitoring

Keywords

  • biomaterial
  • biomedical
  • nanoscale

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Hwang, S. R., Ku, S. H., Joo, M. K., Kim, S. H., & Kwon, I. C. (2014). Theranostic nanomaterials for image-guided gene therapy. MRS Bulletin, 39(1), 44-50. https://doi.org/10.1557/mrs.2013.312

Theranostic nanomaterials for image-guided gene therapy. / Hwang, Seung Rim; Ku, Sook Hee; Joo, Min Kyung; Kim, Sun Hwa; Kwon, Ick Chan.

In: MRS Bulletin, Vol. 39, No. 1, 27.01.2014, p. 44-50.

Research output: Contribution to journalArticle

Hwang, SR, Ku, SH, Joo, MK, Kim, SH & Kwon, IC 2014, 'Theranostic nanomaterials for image-guided gene therapy', MRS Bulletin, vol. 39, no. 1, pp. 44-50. https://doi.org/10.1557/mrs.2013.312
Hwang SR, Ku SH, Joo MK, Kim SH, Kwon IC. Theranostic nanomaterials for image-guided gene therapy. MRS Bulletin. 2014 Jan 27;39(1):44-50. https://doi.org/10.1557/mrs.2013.312
Hwang, Seung Rim ; Ku, Sook Hee ; Joo, Min Kyung ; Kim, Sun Hwa ; Kwon, Ick Chan. / Theranostic nanomaterials for image-guided gene therapy. In: MRS Bulletin. 2014 ; Vol. 39, No. 1. pp. 44-50.
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