Abstract
The concept of personalized medicine has recently emerged as a promising way to address unmet medical needs. Due to the limitations of standard diagnostic and therapeutic strategies, the disease treatment is moving towards tailored treatment for individual patients, considering the inter-individual variability in therapeutic response. Theranostics, which involves the combination of therapy and diagnostic imaging into a single system, may fulfill the promise of personalized medicine. By integrating molecular imaging functionalities into therapy, theranostic approach could be advantageous in therapy selection, treatment planning, objective response monitoring and follow-up therapy planning based on the specific molecular characteristics of a disease. Although the field of therapy and imaging of its response have been independently developed thus far, developing imaging strategies can be fully exploited to revolutionize the theranostic systems in combination with the therapy modality. In this review, we describe the recent advances in molecular imaging technologies that have been specifically developed to evaluate the therapeutic efficacy for theranostic purposes.
| Original language | English |
|---|---|
| Pages (from-to) | 477-484 |
| Number of pages | 8 |
| Journal | Journal of Controlled Release |
| Volume | 190 |
| DOIs | |
| Publication status | Published - 2014 Sep 28 |
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ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Theranostic nanoparticles for future personalized medicine. / Ryu, Ju Hee; Lee, Sangmin; Son, Sohee; Kim, Sun Hwa; Leary, James F.; Choi, Kuiwon; Kwon, Ick Chan.
In: Journal of Controlled Release, Vol. 190, 28.09.2014, p. 477-484.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Theranostic nanoparticles for future personalized medicine
AU - Ryu, Ju Hee
AU - Lee, Sangmin
AU - Son, Sohee
AU - Kim, Sun Hwa
AU - Leary, James F.
AU - Choi, Kuiwon
AU - Kwon, Ick Chan
PY - 2014/9/28
Y1 - 2014/9/28
N2 - The concept of personalized medicine has recently emerged as a promising way to address unmet medical needs. Due to the limitations of standard diagnostic and therapeutic strategies, the disease treatment is moving towards tailored treatment for individual patients, considering the inter-individual variability in therapeutic response. Theranostics, which involves the combination of therapy and diagnostic imaging into a single system, may fulfill the promise of personalized medicine. By integrating molecular imaging functionalities into therapy, theranostic approach could be advantageous in therapy selection, treatment planning, objective response monitoring and follow-up therapy planning based on the specific molecular characteristics of a disease. Although the field of therapy and imaging of its response have been independently developed thus far, developing imaging strategies can be fully exploited to revolutionize the theranostic systems in combination with the therapy modality. In this review, we describe the recent advances in molecular imaging technologies that have been specifically developed to evaluate the therapeutic efficacy for theranostic purposes.
AB - The concept of personalized medicine has recently emerged as a promising way to address unmet medical needs. Due to the limitations of standard diagnostic and therapeutic strategies, the disease treatment is moving towards tailored treatment for individual patients, considering the inter-individual variability in therapeutic response. Theranostics, which involves the combination of therapy and diagnostic imaging into a single system, may fulfill the promise of personalized medicine. By integrating molecular imaging functionalities into therapy, theranostic approach could be advantageous in therapy selection, treatment planning, objective response monitoring and follow-up therapy planning based on the specific molecular characteristics of a disease. Although the field of therapy and imaging of its response have been independently developed thus far, developing imaging strategies can be fully exploited to revolutionize the theranostic systems in combination with the therapy modality. In this review, we describe the recent advances in molecular imaging technologies that have been specifically developed to evaluate the therapeutic efficacy for theranostic purposes.
KW - Molecular imaging
KW - Monitoring response
KW - Personalized medicine
KW - Theranostics
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UR - http://www.scopus.com/inward/citedby.url?scp=84906787631&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2014.04.027
DO - 10.1016/j.jconrel.2014.04.027
M3 - Article
C2 - 24780269
AN - SCOPUS:84906787631
VL - 190
SP - 477
EP - 484
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
ER -