Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy

Yong Il Park, Hyung Min Kim, Jeong Hyun Kim, Kyung Chul Moon, Byeongjun Yoo, Kang Taek Lee, Nohyun Lee, Yoonseok Choi, Wooram Park, Daishun Ling, Kun Na, Woo Kyung Moon, Seung Hong Choi, Hong Seok Park, Soo-Young Yoon, Yung Doug Suh, Sung Ho Lee, Taeghwan Hyeon

Research output: Contribution to journalArticle

291 Citations (Scopus)

Abstract

Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

Original languageEnglish
Pages (from-to)5755-5761
Number of pages7
JournalAdvanced Materials
Volume24
Issue number42
DOIs
Publication statusPublished - 2012 Nov 8

Fingerprint

Lanthanoid Series Elements
Photodynamic therapy
Rare earth elements
Tumors
Nanoparticles
Imaging techniques
Photosensitizing Agents
Photosensitizers
Magnetic resonance
Luminescence
Irradiation
chlorin e6

Keywords

  • luminescence
  • magnetic resonance imaging
  • nanoparticles
  • photodynamic therapy
  • upconversion

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy. / Park, Yong Il; Kim, Hyung Min; Kim, Jeong Hyun; Moon, Kyung Chul; Yoo, Byeongjun; Lee, Kang Taek; Lee, Nohyun; Choi, Yoonseok; Park, Wooram; Ling, Daishun; Na, Kun; Moon, Woo Kyung; Choi, Seung Hong; Park, Hong Seok; Yoon, Soo-Young; Suh, Yung Doug; Lee, Sung Ho; Hyeon, Taeghwan.

In: Advanced Materials, Vol. 24, No. 42, 08.11.2012, p. 5755-5761.

Research output: Contribution to journalArticle

Park, YI, Kim, HM, Kim, JH, Moon, KC, Yoo, B, Lee, KT, Lee, N, Choi, Y, Park, W, Ling, D, Na, K, Moon, WK, Choi, SH, Park, HS, Yoon, S-Y, Suh, YD, Lee, SH & Hyeon, T 2012, 'Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy', Advanced Materials, vol. 24, no. 42, pp. 5755-5761. https://doi.org/10.1002/adma.201202433
Park, Yong Il ; Kim, Hyung Min ; Kim, Jeong Hyun ; Moon, Kyung Chul ; Yoo, Byeongjun ; Lee, Kang Taek ; Lee, Nohyun ; Choi, Yoonseok ; Park, Wooram ; Ling, Daishun ; Na, Kun ; Moon, Woo Kyung ; Choi, Seung Hong ; Park, Hong Seok ; Yoon, Soo-Young ; Suh, Yung Doug ; Lee, Sung Ho ; Hyeon, Taeghwan. / Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy. In: Advanced Materials. 2012 ; Vol. 24, No. 42. pp. 5755-5761.
@article{4809f2ce342e44e8ac02a4cd4326653e,
title = "Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy",
abstract = "Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.",
keywords = "luminescence, magnetic resonance imaging, nanoparticles, photodynamic therapy, upconversion",
author = "Park, {Yong Il} and Kim, {Hyung Min} and Kim, {Jeong Hyun} and Moon, {Kyung Chul} and Byeongjun Yoo and Lee, {Kang Taek} and Nohyun Lee and Yoonseok Choi and Wooram Park and Daishun Ling and Kun Na and Moon, {Woo Kyung} and Choi, {Seung Hong} and Park, {Hong Seok} and Soo-Young Yoon and Suh, {Yung Doug} and Lee, {Sung Ho} and Taeghwan Hyeon",
year = "2012",
month = "11",
day = "8",
doi = "10.1002/adma.201202433",
language = "English",
volume = "24",
pages = "5755--5761",
journal = "Advanced Materials",
issn = "0935-9648",
publisher = "Wiley-VCH Verlag",
number = "42",

}

TY - JOUR

T1 - Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy

AU - Park, Yong Il

AU - Kim, Hyung Min

AU - Kim, Jeong Hyun

AU - Moon, Kyung Chul

AU - Yoo, Byeongjun

AU - Lee, Kang Taek

AU - Lee, Nohyun

AU - Choi, Yoonseok

AU - Park, Wooram

AU - Ling, Daishun

AU - Na, Kun

AU - Moon, Woo Kyung

AU - Choi, Seung Hong

AU - Park, Hong Seok

AU - Yoon, Soo-Young

AU - Suh, Yung Doug

AU - Lee, Sung Ho

AU - Hyeon, Taeghwan

PY - 2012/11/8

Y1 - 2012/11/8

N2 - Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

AB - Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

KW - luminescence

KW - magnetic resonance imaging

KW - nanoparticles

KW - photodynamic therapy

KW - upconversion

UR - http://www.scopus.com/inward/record.url?scp=84868357461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868357461&partnerID=8YFLogxK

U2 - 10.1002/adma.201202433

DO - 10.1002/adma.201202433

M3 - Article

C2 - 22915170

AN - SCOPUS:84868357461

VL - 24

SP - 5755

EP - 5761

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 42

ER -