Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy

Yong Il Park, Hyung Min Kim, Jeong Hyun Kim, Kyung Chul Moon, Byeongjun Yoo, Kang Taek Lee, Nohyun Lee, Yoonseok Choi, Wooram Park, Daishun Ling, Kun Na, Woo Kyung Moon, Seung Hong Choi, Hong Seok Park, Soo-Young Yoon, Yung Doug Suh, Sung Ho Lee, Taeghwan Hyeon

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300 Citations (Scopus)

Abstract

Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

Original languageEnglish
Pages (from-to)5755-5761
Number of pages7
JournalAdvanced Materials
Volume24
Issue number42
DOIs
Publication statusPublished - 2012 Nov 8

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Keywords

  • luminescence
  • magnetic resonance imaging
  • nanoparticles
  • photodynamic therapy
  • upconversion

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Park, Y. I., Kim, H. M., Kim, J. H., Moon, K. C., Yoo, B., Lee, K. T., Lee, N., Choi, Y., Park, W., Ling, D., Na, K., Moon, W. K., Choi, S. H., Park, H. S., Yoon, S-Y., Suh, Y. D., Lee, S. H., & Hyeon, T. (2012). Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy. Advanced Materials, 24(42), 5755-5761. https://doi.org/10.1002/adma.201202433