Therapeutic effect of erythroid differentiation regulator 1 (Erdr1) on collagen-induced arthritis in DBA/1J mouse

Kyung Eun Kim, Sungryung Kim, Sunyoung Park, Younkyung Houh, Yoolhee Yang, Seung Beom Park, Sangyoon Kim, Daejin Kim, Dae Young Hur, Seonghan Kim, Hyun Jeong Park, Sa Ik Bang, Dae Ho Cho

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1 Citation (Scopus)

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and multiple inflammatory cytokines are involved in RA pathogenesis. Interleukin (IL)-18, in particular, has a significant positive correlation with RA. In this study, we investigated the effect of erythroid differentiation regulator 1 (Erdr1), which is negatively regulated by IL-18, in an animal model of inflammatory arthritis, collageninduced arthritis (CIA) in DBA/1J mice. Treatment of mice with recombinant (r) Erdr1 significantly suppressed the severity of arthritis, histologic features of arthritic tissue, and serum levels of anti-collagen autoantibodies (IgG, IgG1, IgG2a and IgM) in CIA. In addition, IL-18 expression was reduced in the affected synovium of rErdr1-treated mice. Interestingly, Erdr1 treatment suppressed migration in contrast to the pro-migratory effect of IL-18, indicating the therapeutic effects of Erdr1 on CIA through inhibiting synovial fibroblast migration. In addition, Erdr1 inhibited activation of ERK1/2, a key signaling pathway in migration of various cell types. Taken together, these data show that rErdr1 exerts therapeutic effects on RA by inhibiting synovial fibroblast migration, suggesting that rErdr1 treatment might be an effective therapeutic approach for RA.

Original languageEnglish
Pages (from-to)76354-76361
Number of pages8
JournalOncotarget
Volume7
Issue number47
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

Keywords

  • Erythroid differentiation regulator 1 (Erdr1)
  • Immune response
  • Immunity
  • Immunology and Microbiology Section
  • Inflammation
  • Interleukin-18 (IL-18)
  • Rheumatoid arthritis
  • Synovial fibroblast migration

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Kim, K. E., Kim, S., Park, S., Houh, Y., Yang, Y., Park, S. B., Kim, S., Kim, D., Hur, D. Y., Kim, S., Park, H. J., Bang, S. I., & Cho, D. H. (2016). Therapeutic effect of erythroid differentiation regulator 1 (Erdr1) on collagen-induced arthritis in DBA/1J mouse. Oncotarget, 7(47), 76354-76361. https://doi.org/10.18632/oncotarget.13047