Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries

Ji Hun Jung, Hyun-Tae Park, Tak Kim, Moon Jin Jeong, Sung Chul Lim, Seung Yeol Nah, Ik Hyun Cho, Soo Hyun Park, Seong Soo Kang, Chang Jong Moon, Jong Choon Kim, Sung Ho Kim, Chun Sik Bae

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in an estradiol valerate (EV)-induced rat model. Polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. KRGE was administered orally (200 mg/kg body weight/day) for 60 consecutive days, beginning 60 days after the induction. Ovarian morphology was almost normalized and NGF was normalized in the EV+KRGE group. KRGE lowered the high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries. The results are consistent with a beneficial effect of KRGE in the treatment of PCOS.

Original languageEnglish
Pages (from-to)250-255
Number of pages6
JournalJournal of Ginseng Research
Volume35
Issue number2
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

estradiol valerate
Panax
Therapeutic Uses
Nerve Growth Factor
Infertility
polycystic ovary syndrome
Ovary
nerve growth factor
Polycystic Ovary Syndrome
therapeutics
Rats
extracts
Sesame Oil
Valerates
estradiol
endocrine diseases
sesame oil
Corpus Luteum
Intramuscular Injections
intramuscular injection

Keywords

  • Estradiol valerate
  • Ginseng extract
  • Panax ginseng
  • Pathophysiology
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Complementary and alternative medicine

Cite this

Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries. / Jung, Ji Hun; Park, Hyun-Tae; Kim, Tak; Jeong, Moon Jin; Lim, Sung Chul; Nah, Seung Yeol; Cho, Ik Hyun; Park, Soo Hyun; Kang, Seong Soo; Moon, Chang Jong; Kim, Jong Choon; Kim, Sung Ho; Bae, Chun Sik.

In: Journal of Ginseng Research, Vol. 35, No. 2, 01.06.2011, p. 250-255.

Research output: Contribution to journalArticle

Jung, JH, Park, H-T, Kim, T, Jeong, MJ, Lim, SC, Nah, SY, Cho, IH, Park, SH, Kang, SS, Moon, CJ, Kim, JC, Kim, SH & Bae, CS 2011, 'Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries', Journal of Ginseng Research, vol. 35, no. 2, pp. 250-255. https://doi.org/10.5142/jgr.2011.35.2.250
Jung, Ji Hun ; Park, Hyun-Tae ; Kim, Tak ; Jeong, Moon Jin ; Lim, Sung Chul ; Nah, Seung Yeol ; Cho, Ik Hyun ; Park, Soo Hyun ; Kang, Seong Soo ; Moon, Chang Jong ; Kim, Jong Choon ; Kim, Sung Ho ; Bae, Chun Sik. / Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries. In: Journal of Ginseng Research. 2011 ; Vol. 35, No. 2. pp. 250-255.
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